Banca de DEFESA: NEANDDER ANDRADE CORREIA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
DISCENTE : NEANDDER ANDRADE CORREIA
DATA : 29/05/2020
HORA: 09:00
LOCAL: Plataforma Conferência Web da RNP
TÍTULO:

DETECTION OF PROSTATE CANCER BY RAMAN SPECTROSCOPY: A MULTIVARIATE STUDY IN PATIENTS WITH

NORMAL AND CHANGED PSA VALUES.

PALAVRAS-CHAVES:

PCA; PLS; PSA; Prostate Malignancy; Vibrational Spectroscopy.

PÁGINAS: 62
GRANDE ÁREA: Outra
ÁREA: Tecnologia e Inovação
RESUMO:

Digital rectal examination (DRE) was the primary means to detect prostate diseases. The DRE has a high variability asit is based manly in the tactile sensitivity and expertise of the examiner. The PSA test was initially developed for surveillance of prostate cancer and later itwas also used as a diagnosis test. Raman spectroscopy is a powerful analytical technique that can measure the chemical composition of complex biological samples, such as body fluids. Biochemical changes caused by diseases can lead to significant changes in the Raman spectra. We aimed to identify the differences in the Raman spectra of serum samples with normal and altered PSA values and correlate these differences by using multivariate techniques (PCA and PLS). A total of 321 spectra were collected. Two hundred and seventy were obtained from 90 nonaltered PSA samples and 51 spectra from 17 samples with altered PSA. Each spectrum acquired was standardized to the highest peak. Discriminating models employing PCA and PLS (PCA and PLS) were developed. The PCA analyses showed 85.7 % predictive power (87.41 % sensitivity and 76.47% specificity). The PLS test showed a near-perfect sensitivity (98.51 %) and an intermediate specificity (62.75 %). This preliminary study is indicative that Raman spectroscopy could be efficiently used for screening patients with altered PSA as well as for follow-up of the treatment of the prostate cancer by using initially the PLS to identify the possible presence of the prostate cancer and later on use de PCA to confirm the diagnosis.

MEMBROS DA BANCA:
Presidente - 1134693 - ANTONIO LUIZ BARBOSA PINHEIRO
Interno - 1227468 - JEAN NUNES DOS SANTOS
Externo à Instituição - JULIANA SANTOS DE CARVALHO MONTEIRO - UEFS
Externo à Instituição - PEDRO JORGE LOURO CRUGEIRA
Externo à Instituição - SUSANA CARLA PIRES SAMPAIO - UniRuy