Banca de DEFESA: CEZAR MIGUEL SANTOS JUNIOR

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : CEZAR MIGUEL SANTOS JUNIOR
DATE: 07/12/2021
TIME: 09:00
LOCAL: Conferência Web
TITLE:

Isolation and characterization of coumarins obtained from the stem bark of Metrodorea mollis

KEY WORDS:

Metrodorea; coumarins; phytochemistry

PAGES: 172
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUBÁREA: Farmacognosia
SUMMARY:

The brazilian flora has around 50.000 identified species, wich means 22% of the existing vegetation worlwide. However, there are also many species without proper identification, specially the ones from northeastern region of Brazil. The genus Metrodorea (Rutaceae) comprises 6 species ranging between shrubs and trees, which are found exclusively in South America, and which belongs to the vegetation found in Chapada Diamantina National Park. Among the species found in Metrodorea, M. mollis has, so far, just one report regarding its phytochemical composition. However, there was no information about the part of the plant used for compounds isolation. In this contexto, this study aimed to fractionate the crude extracts obtained from stem barks of M. mollis, in order to provide accurate information about obtaining active compounds from this plant. Stem barks from M.mollis were collected in March 2005 in the district of Catolés, located in Abaira city, Chapada Diamantina-Bahia, Brazil. The plant was identified and deposited in Alexandre Leal Costa Herbarium by the voucher number 69153. Air-dried stem barks of M.mollis were macerated with hexane and methanol in order to obtain its corresponding extracts, which were fractionated by column chromatography and eluted with ethyl acetate and hexane and/or chloroform in gradient system. NMR 1H and 13C analyzes provided the identification of six coumarins: braylin (1), isopimpinellin (2), xanthoxotin (3), xanthoxyletin (4), alloxanthoxyletin (5), luvagentin (6). This study is the first to bring information about isolation and characterization of compounds (5) and (6) among all the Metrodorea genra.

BANKING MEMBERS:
Presidente - 1281669 - RENATA BIEGELMEYER DA SILVA RAMBO
Externo ao Programa - 1068075 - JORGE MAURICIO DAVID
Externo à Instituição - ALEXSANDRO BRANCO - UEFS