Banca de DEFESA: ANA FLAVIA SOUTO FIGUEIREDO NEPOMUCENO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ANA FLAVIA SOUTO FIGUEIREDO NEPOMUCENO
DATE: 17/02/2022
TIME: 09:00
LOCAL: Conferência Web
TITLE:

New analytical strategy for determination of mefenamic acids in drugs by colorimetry of digital images. 

KEY WORDS:

Digital image colorimetry; Mefenamic acid; Liquid phase microextraction; Medicines.

PAGES: 62
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

The development of a new, simple, fast and low-cost analytical strategy for the determination of mefenamic acid in drug samples is described in this work. The proposal was based on the pre-concentration of mefenamic acid, using ultrasound-assisted liquid-phase microextraction (UA-LPME) and subsequent detection by digital image colorimetry (ID). The UA-LP with a eutectic solvent consisting of thymol and product (obtaining solvent) and a copper sulfate solution. Univariate optimization, optimal adjustment conditions such as working solvent samples, time adjustment and pH adjustment, adjustment solution type, solvent time adjustment, adjustment time adjustment and pH adjustment. Under optimized conditions, the new method had a detection limit of 0.43 µg/mL, a limit of quantitation of 1.31 µg, and an accuracy (relative standard deviation) of 2.38%. The method precision was made by means of comparison with the reference method of Ab or Atomic Spectrometry with Graphite Furnace at 95% confidence. In the analyzed samples, for 500 mg drugs, mean concentrations in the range of 499 to 532 mg of mefenamic acid were found. The proposed procedure was successfully applied to the determination of mefenamic acid in a sample of drugs sold in the city of Salvador, Bahia, Brazil. The method complies with the principles of environmental chemistry as it uses a small risk of green sample materials and according to the developed method generates a small risk of green sample materials and uses a low risk product model and according to the potential of ambient reagent.

BANKING MEMBERS:
Interna - 2053589 - EDITH CRISTINA LAIGNIER CAZEDEY
Presidente - 030.069.065-78 - LIZ OLIVEIRA DOS SANTOS - UFBA
Externo à Instituição - MARCOS DE ALMEIDA BEZERRA - UESB