Banca de DEFESA: ANANDA FREITAS FONSECA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ANANDA FREITAS FONSECA
DATE: 14/12/2021
TIME: 14:30
LOCAL: Faculdade de Farmácia
TITLE:

DEVELOPMENT OF THE POPULATION PHARMACOKINETIC MODEL OF BUPROPIONA USING LITERATURE DATA

KEY WORDS:

release systems, population pharmacokinetics, pharmacokinetic modeling

 

PAGES: 39
BIG AREA: Ciências Biológicas
AREA: Farmacologia
SUBÁREA: Farmacologia Clínica
SUMMARY:

Introduction: Depression is one of the most common psychiatric disorders, due to the high incidence in this decade, a greater prevalence in women, including major depressive disorder in pregnancy. When the diagnosis is made, the treatment occur according to the degree of the disease and when this degree is moderate to severe, pharmacological treatment with antidepressants is started. Among them, the most prescribed drugs are selective serotonin reuptake inhibitors, they are taken first-line drugs because they are safer than the others. Bupropion is reported in the literature as a second-generation SSRI antidepressant, which has three different release systems: immediate (IR), sustained (SR) and extended (XL). Objective: The objective of this study is to develop a population pharmacokinetic model using literature data to assess the pharmacokinetic profile of bupropion in its three delivery systems (IR, SR and XL) in addition to analyzing the influence of the covariates sex and smoking. Methodology: For this, an exploratory search was carried out with well-established inclusion, non-inclusion and exclusion criteria in order to find articles that had performed pharmacokinetic studies in human subjects and administered bupropion in any of its delivery and dose systems. Another essential feature of these studies is to contain at least one graph of concentration versus time with sufficient definition for their data to be extracted using the WebPlot Digitizer software. After getting the data, the population pharmacokinetic model was developed using the Monolix® Suite 2020R1 software. Results: After applying the research strategies, it was reached an number of 5 articles that corresponded to the characteristics necessary to perform the data extraction and the scope of the population pharmacokinetic model that harmoniously adjusts and explains the studied covariates. As a result, we obtained a one-compartment model, with zero-order absorption, linear elimination and considering the lag time related to the different release systems. Furthermore, we could see that the covariates sex and smoking do not influence the pharmacokinetics of bupropion, as found in other studies. Conclusion: The population pharmacokinetic model developed from information extracted from studies in the literature was able to adapt the data from these studies and explore the proposed covariates. As expected, the type of delivery system has a strong interaction with drug release delay time. On the other hand, the covariates sex and smoking do not influence the pharmacokinetic parameters of bupropion.

BANKING MEMBERS:
Presidente - 2055299 - ANA LEONOR PARDO CAMPOS GODOY
Interno - 1490663 - RICARDO DAVID COUTO
Externa à Instituição - SANDRA ELISA HAAS - Unipampa