Banca de DEFESA: KATHARINE VALÉRIA SARAIVA HODEL

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : KATHARINE VALÉRIA SARAIVA HODEL
DATE: 29/11/2021
TIME: 09:00
LOCAL: Faculdade de Farmácia
TITLE:

DEVELOPMENT AND CHARACTERIZATION OF BASE BIOCURATIVES OF BACTERIAL CELLULOSE INCORPORATED WITH P-CUMARIC ACID, BIOCHANIN A AND GREEN AND RED PROPOLIS EXTRACT

KEY WORDS:

bacterial cellulose; biopolymers; biocuratives; dermal lesions; propolis; p-coumaric acid; biochanin A

PAGES: 90
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUBÁREA: Análise e Controle de Medicamentos
SUMMARY:

Bacterial cellulose (BC) is one of the great bets of the biomedical sector because of its unique properties that are essential for an ideal dressing. Among them, the possible incorporation of molecules that have an active action in the healing process. Propolis and its biocomponents (biomarkers) are considered important candidates for incorporation in BC membranes for application as dressings, since they have important biological activities for tissue regeneration. In this context, the aim of this study was to develop and characterize BC-based biocuratives incorporated with green and red propolis extracts, as well as the active compounds p-coumaric acid and biochanin A. In total, nine biocuratives were developed (one control and eight active biocuratives) that were characterized for morphological, optical, physical and barrier, tensile mechanical, antioxidant and antimicrobial properties. The in vitro permeation using Franz diffusion cells of the biocuratives formed by CB and the active substances was also performed. Within this context, the characterization of the nine samples developed, where the transparency (28.59-110.62 T600.mm-1 ), opacity (28.43-50.48 Abs500.mm-1 ), weight (0.004-0.009 g.cm-2 ), thickness (0.023-0.046 mm), aw (0.292-0.455), water solubility (6.25-65.58 %), moisture content index (27.44-84.87 %), intumescence index (48.93-405.55 %), water vapor permeability rate (7.86-38.11 g.m².day-1 ), water vapor permeability (2.29-10.30 g-mm/m²-day-1), maximum stress (0.53-4.15 MPa), elongation (99.13-262.39 %), total flavonoid content (0.05-39.16 mg EQ.g-1 ), DPPH radical scavenging capacity (21.23-86.76 µg.mL1 ) were determined. The biocuratives based on BC and red propolis extract were the only ones that showed antimicrobial activity against Escherichia coli. The permeation and retention assay showed that the biocuratives containing propolis extract showed a higher concentration in the stratum corneum when compared to viable skin. The results showed, in general, that the presence and concentration of the active compound in the cellulosic matrix interferes in the characterization tests performed. Thus, the different performances as to the properties evaluated suggest that they have a potential application for different types of skin lesions, as well as for different phases of healing.

BANKING MEMBERS:
Presidente - 2055299 - ANA LEONOR PARDO CAMPOS GODOY
Externa ao Programa - 4725209 - CAROLINA OLIVEIRA DE SOUZA
Externa ao Programa - 287717 - TANIA FRAGA BARROS