Banca de DEFESA: ROMULA BETANIA MENDES ALECRIM DA ROCHA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : ROMULA BETANIA MENDES ALECRIM DA ROCHA
DATA : 28/08/2019
HORA: 15:00
LOCAL: Sala 07 Faculdade de Farmácia
TÍTULO:

EXPOSURE TO SMOKE FROMM WOOD BURNING AND LEAD OF THE POTTERY WORSHOPS AND HEALTH EFFECTS ONSCHOOL-AGED CHILDREN IN MARAGOGIPINHO, BAHIA

PALAVRAS-CHAVES:

Children; Particulate Material; Lead; Respiratory function; Environmental Exposure.

PÁGINAS: 96
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
SUBÁREA: Análise Toxicológica
RESUMO:

ntroduction: Air pollutants are crucial for the disease process, especially with regard to respiratory diseases. Noteworthy is the burning of biomass that generates numerous compounds, including particulate matter (PM), one of the main pollutants that has environmental importance and toxicological interest. Objective: To evaluate the exposure to smoke from wood burning and lead (Pb) from the potteries of Maragogipinho, Aratuípe, Bahia and to investigate its association with health effects on school-aged children from this locality. Methodology: This cross-sectional study included 72 children aged 6 to 14 years, of both sexes, enrolled in elementary schools in Vila de Maragogipinho and classified as moderate exposure (MEx) and low exposure (BEx) according to the deposition rates of Pb in the dust. These were compared with 71 children from schools located in the urban center of the municipality Aratuípe, called control group (CG). Sociodemographic data, anthropometric parameters were recorded and the frequencies of asthma, rhinitis and allergies were determined using the ISAAC questionnaire. Data on blood lead levels (PbS) were collected from the CAS (Lead, Environment and Health) study. One hundred and eighteen children (82.5%) had their blood pressure (BP) measured and underwent respiratory function test using a portable digital spirometer. Results: Of the total children evaluated (n = 143), 77 (53.85%) were female, the median age in group BEx was 8.41 (6.7 - 13.87) years, group MEx was 10.87 (5.9 - 14.04) and in the GC group it was 11.91 (7.65 - 14.17) years. The blood lead had a median of 2.3 μg / dL (ranging from 0.1 μg / dL to 21.3 μg / dL). The children's BP presented values within the normal range, with no significant difference for systolic and diastolic BP in both groups (p = 0.088 and p = 0.077, respectively). However, in the MEx group, a slight increase in the 95th and 99th percentiles of both systolic and diastolic BP was detected in 4.9% of children. However, in the CG, a slight increase was observed in the 90th, 95th and 99th percentiles for systolic BP with 5.9% of children and a slight increase only in the 99th percentile for diastolic BP with 1.5% of children, which can be classified as hypertensive (HP). There was no significant correlation between the systolic and diastolic BP variables and PbS levels. A high frequency of asthma symptoms was observed in 65% of children in the MEx group, 44.1% in the BEx group and 50% in the CG, but there was no significant difference (p = 0.163) between the groups. The frequency of allergic rhinitis was 38.2% in the BEx group, 47.5% in the MEx group and 30.9% in the CG. The results for respiratory function parameters such as forced vital capacity (% FVC) and forced expiratory volume in one second (% FEV1) tended to decrease with increased of blood lead in the BEx and MEx groups, but with low values (R2 = 0.006 and R2 = 0.061; R2 = 0.013 and R2 = 0.056 respectively). Blood lead levels were significantly correlated (p <0.05) with Z-score Height / Age, Weight and BMI and with respiratory parameters %FEF25-75 and %PEF.  Conclusions: These findings confirm growing evidence that air pollution may be directly linked to health problems for the population, especially the child population. For a better stratification of the results it would be necessary to carry out a clinical monitoring of the respiratory function measurement of these children and to quantify the PM concentrations in several points of this locality.

MEMBROS DA BANCA:
Presidente - 2181841 - JOSE ANTONIO MENEZES FILHO
Interno - 2055299 - ANA LEONOR PARDO CAMPOS GODOY
Externo ao Programa - 1864328 - MANSUETO GOMES NETO