Banca de DEFESA: ALEX BRUNO DA SILVA SOUZA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : ALEX BRUNO DA SILVA SOUZA
DATA : 16/05/2019
HORA: 09:00
LOCAL: Faculdade de Farmácia
TÍTULO:

Evaluation of cytokines in alcoholic patients Strongyloides stercoralis infected

PALAVRAS-CHAVES:

Strongyloides stercoralis. Alcoholics. Cytokines.

PÁGINAS: 50
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
SUBÁREA: Análise Toxicológica
RESUMO:

Strongyloides stercoralis infection prevalence is high in alcoholic patients. Excessive alcohol consumption increases the levels of endogenous corticosteroids, which mimic the effect of the ecdysone, a parasitic hormone which stimulates the differentiation of rabditoid into infectious filarioid larvae. The immune response to strongyloidiasis in immunocompromised patients is usually associated with a Th2 cellular response profile. The aim of this study was to evaluate serum levels of cytokines (INF-γ, IL-2, IL-4, IL-5, IL-10, IL-15, IL-17) in alcoholic patients infected with S. stercoralis and to correlate its levels with the parasite load. S. stercoralis frequency was evaluated in 336 alcoholic patients attended at the Centro de Acolhimento e Tratamento de Alcoolistas (CATA), Obras Sociais Irmã Dulce, Salvador, BA, from April 2017 to August 2018. The parasitological diagnosis was performed by three methods: agar plate culture, Baermann-Moraes and spontaneous sedimentation in, at least, two fecal samples from each patient on alternate days. Serum cytokines levels were determined in 88 sera from S. stercoralis  infected (n = 24) and non-infected (n = 24) alcoholic patients and S. stercoralis  infected (n = 20) and non-infected (n = 20) non-alcoholic individuals (n = 20). S. stercoralis infection frequency in alcoholic patients was 16.1% (54/336). Among the evaluated cytokines, a statistically significant elevation in IL-10 and IL-15 levels was observed in patients compared to S. stercoralis infected non-alcoholics individuals (p <0.05). A negative correlation was demonstrated between the concentration of INF-γ and IL-17 with the parasite load of alcoholic patients. Thus, it is probably that alcohol is inducing the simultaneous elevation of both pro-inflammatory and regulatory cytokines, IL-15 and IL-10, respectively. The negative correlation of INF-γ and IL-17 concentrations with the parasite load probably reflects on the modulation of the T reg cells in the control of the strongyloidiasis.

MEMBROS DA BANCA:
Presidente - 2178405 - NECI MATOS SOARES
Interno - 287210 - FERNANDA WASHINGTON DE MENDONCA LIMA
Interno - 3187360 - MARCIA CRISTINA AQUINO TEIXEIRA
Externo ao Programa - 1561789 - RICARDO WAGNER DIAS PORTELA
Externo à Instituição - JOELMA NASCIMENTO DE SOUZA - EBMSP