Banca de DEFESA: JACKELINE MARLEY SANTOS DE ARAÚJO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : JACKELINE MARLEY SANTOS DE ARAÚJO
DATE: 21/11/2023
TIME: 14:00
LOCAL: Portal RNP
TITLE:

Physiology based pharmacokinetic modeling of methylphenidate in adults

KEY WORDS:

Methylphenidate; Physiology-Based Pharmacokinetic Modeling; PK-Sim^®; Tutorial.

PAGES: 79
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Introduction: Methylphenidate (MPH) is a psychotropic stimulant drug used as first pharmacological choice for treating Attention/Hyperactivity Deficit Disorder (ADHD). However, problems related to their use make further investigation of their pharmacokinetics (PK) in treating ADHD in the adult population needed. Physiology-based Pharmacokinetic modeling (PBPK) is a mathematical approach that aims to simulate concentration profiles versus time for different administration pathways integrating the physiological structure of a particular species and physicochemical characteristics of a compound. PK-Sim^® is free open-source software developed by Open Systems Pharmacology (OSP) to construct full-body PBPK models. It can be used to simulate different species, characterizing their respective organisms in different biological compartments. Objective: The central objective of this work was to evaluate the variability of exposure after the use of MPH in adults. Methodology: A PBPK model for MPH was developed in PK-Sim^® software (version 11.2) using information obtained from Literature on MPH, adult individuals, and two types of formulations. Results and Discussion: A PBPK model has been developed and validated whose predictive performance adequately meets the predefined criteria PK characteristics in Caucasian individuals and in a Caucasian population using a modified release formulation. Complementarily, a PK-Sim^®-based tutorial was developed to enable readers to perform a PBPK analysis to provide a mechanistic approach to study and predict the PK of compounds based on the physiological and anatomical characteristics of a population of interest, as well as in the physical and chemical properties of a certain drug, as well as encouraging the production and teaching of Pharmaceutical Sciences among Portuguese speakers. Conclusion: This study properly verified the variability of exposure to MPH use in human adults. In addition, it also produced a Portuguese tutorial guiding PBPK modeling using PK-Sim^®.

COMMITTEE MEMBERS:
Presidente - 1012812 - FRANCINE JOHANSSON AZEREDO
Externa ao Programa - 3163159 - IZABEL ALMEIDA ALVES - UFBAExterna à Instituição - ANDREA DINIZ - UEM