Banca de DEFESA: LAIZ CAMPOS PEREIRA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : LAIZ CAMPOS PEREIRA
DATE: 14/12/2022
TIME: 14:30
LOCAL: Plataforma RNP
TITLE:

Amphotericin B Pharmacokinetic/pharmacodynamic modeling against Candida Albicans

KEY WORDS:

Amphotericin B. Invasive candidiasis. C. albicans. Pharmacokinetic/ Pharmacodynamic modeling. Pharmacometrics

PAGES: 82
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Invasive fungal infections (IFIs) are considered a public health problem, and recent studies have shown that the Candida albicans is responsible for most cases. For the treatment of this type of infection, antifungal drugs that belong to the classes of azoles, polyenes, and echinocandins are used, but factors such as fungal resistance, adverse effects related to toxicity, and interactions between drugs difficult the therapeutic success of the treatment. Amphotericin B (AmB), the only representative of the polyene class, presents a broad spectrum of antifungal action and lower resistance rates, with AmB associated with sodium deoxycholate (AmB), considered the conventional formulation, the most used in Brazilian public hospitals. In order for the pharmacological treatment to be successful, it is necessary to have an in-depth knowledge of both the pharmacokinetic (PK) and the pharmacodynamic (PD) aspects of the drug, and the pharmacokinetic-pharmacodynamic (PK/PD) modeling is considered the most effective approach to assess the effectiveness of antifungal agentes. Therefore, this work aimed to develop a PK/PD modeling of AmB deoxycholate against C. albicans. This work consists two chapters: (i) review article about main approaches of the PKPD modeling and studies applying this approache with antibacterials and antifungals; (ii) PK/PD modeling of antifungal effect of AmB-D agains C. albicans, by time-kill curves obtained fram na in vitro model, with satic and dynamic concentrations. For the PK/PD modeling, it was be an adapted sigmoidal Emax model by software Monolix ®. From the obtained parameters (Emax and EC50), it was possible to assess the potency and effectiveness of AmB Against C. albicans, and comparing the results from two different methodologies.

COMMITTEE MEMBERS:
Presidente - 1012812 - FRANCINE JOHANSSON AZEREDO
Interna - 2055299 - ANA LEONOR PARDO CAMPOS GODOY
Externa à Instituição - BIBIANA VERLINDO DE ARAUJO - UFRGS