Banca de DEFESA: MIGUEL DE JESUS OLIVEIRA SANTOS

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : MIGUEL DE JESUS OLIVEIRA SANTOS
DATE: 15/12/2022
TIME: 14:00
LOCAL: Plataforma RNP (Sala do PPgFAR)
TITLE:

EVALUATION OF MICROALGAE IN OBTAINING PHARMACEUTICAL PRODUCTS AND TREATMENT OF THEIR WASTE

KEY WORDS:

Microalgae; Circular economy; Biorefinery; Bioremediation; Pharmaceutical industry

PAGES: 166
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUBÁREA: Farmacotecnia
SUMMARY:

By introducing the concept of biorefinery for microalgae, a circular economy system can be envisaged in the pharmaceutical industry. This system is based on the extraction of active pharmaceutical ingredients and excipients and their bioremediation in wastewater and effluents containing the same components as well as other residues. Therefore, the aim of this work is to analyze the feasibility of microalgae biorefineries in the pharmaceutical industry on two fronts. Thus, a literature review on the bioremediation of drug contaminated media by microalgae is presented in this work. In addition, an extract of the protein fraction of the microalgae Arthrospira sp. LEB-18 was obtained for further investigation. During the literature review, it was found that microalgal systems are similarly efficient as conventional treatment methods in removing drugs from water. The growth of microalgae exposed to the drug does not appear to be affected at realistic concentrations. The main removal mechanism is biodegradation. In the experiments, Arthrospira platensis LEB-18 was microencapsulated in Eudragit® L100 at a 22 full factorial design. The entrapment efficiency was related to the larger polymer to biomass ratio. No changes in the chemical profiles of the raw materials were observed in the microparticles, which also exhibited a semi-crystalline profile. Microscopic images showed microparticles but also larger biomass fragments that were not fully encapsulated. In vitro digestibility tests indicated protection of the proteinaceous fraction of the encapsulated biomass. The feasibility of a pharmaceutical biorefinery could be achieved in the short to medium term if technological breakthroughs in research are confirmed.

COMMITTEE MEMBERS:
Presidente - 3062920 - HENRIQUE RODRIGUES MARCELINO
Interna - 1211160 - NEILA DE PAULA PEREIRA
Externa à Instituição - SÍLVIA STANISÇUASKI GUTERRES - UFRGS