Banca de DEFESA: DULCE BRAS IMPENE COMBO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : DULCE BRAS IMPENE COMBO
DATE: 04/05/2023
TIME: 14:30
LOCAL: NUTS - HUPES
TITLE:

EVALUATION OF SIMPLIFIED ANTIRETROVIRAL TREATMENT IN A UNIVERSITY HOSPITAL OF SALVADOR, BAHIA

KEY WORDS:

 HIV-1; double therapy; antiretroviral treatment; virological response.

PAGES: 76
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Introduction: Antiretroviral treatment and adherence to therapy have been the most effective intervention in controlling disease progression, although the human immunodeficiency virus (HIV) remains an important global public health problem. Recent studies have shown that dual therapy improves adherence and clinical outcomes and can potentially decrease toxicity and costs associated with treatment. Objective: To evaluate the virological outcomes of simplified antiretroviral regimens prescribed in a University Hospital in the State of Bahia, Brazil. Methods: This is a retrospective observational cohort conducted at the Magalhães Neto Outpatient Clinic, linked to Professor Edgard Santos University Hospital of the Federal University of Bahia (UFBA). Data were collected from January 2017 to August 2022. We included patients older than 18 years, who had already been submitted to antiretroviral therapeutic regimens in the past, without distinction of sex, and with simplified ART. Data were analyzed using the statistical software JAMOVI, version 2.2.5. Descriptive analyses were performed using frequency tables for categorical variables and median and interquartile range for continuous variables. To analyze the individual association of each qualitative independent variable with the dependent variable, Pearson's chi-square test (significance level of 5%) was used. For the joint association between the independent variables and the dependent variable, the data were analyzed by adjusting a binomial logistic regression model. Results and discussion: We analyzed 244 patients of which 65.2% were male, the median age was 58 years (IQR 50-65), evidencing an aging of PLHIV. Virological suppression corresponded to 98% of the patients, with a median time of 60.50 weeks (IQR 29.25-160.25) and a median of CD4 cells cel/mm3 of 675.00 (IQR 478.50-925.25), moreover, 89.7% of the patients prescribed the DTG+3TC regimen had no history of previous therapeutic failure, while 47.5% of the patients submitted to other therapeutic regimens had already had a history of failure. In addition, 88.1% of the patients did not change simplified regimens, which evidences an effectiveness and therapeutic optimization. Conclusion: The results corroborate the literature, demonstrating a good virological response in simplified regimens, and being a safe and effective alternative even in patients with a history of previous therapeutic failure.

COMMITTEE MEMBERS:
Externo à Instituição - Michael Ruberson Ribeiro da Silva - UFES
Externo ao Programa - 287953 - CARLOS ROBERTO BRITES ALVES - nullPresidente - 8347612 - LUCIA DE ARAUJO COSTA BEISL NOBLAT
Interno - 2556460 - PABLO DE MOURA SANTOS