Banca de DEFESA: PAULO CESAR OLIVEIRA SOBRINHO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : PAULO CESAR OLIVEIRA SOBRINHO
DATA : 05/03/2021
HORA: 08:00
LOCAL: Remotamente
TÍTULO:

APLICABILIDADE DO PLASMA RICO EM PLAQUETAS-PRP NO TRATAMENTO DE ÚLCERAS EM PÉ DE PACIENTES DIABÉTICO: REVISÃO SISTEMÁTICA E META-ANÁLISE

PALAVRAS-CHAVES:

Diabetic foot. Platelet rich plasma. Randomied controlled trails.

PÁGINAS: 80
GRANDE ÁREA: Ciências da Saúde
ÁREA: Saúde Coletiva
RESUMO:

Platelet-rich plasma (PRP) is an innovative, promising technique with significant results in several areas of medicine. The aim of this study is to carry out an evaluation of the results on the applicability of PRP in the treatment of foot ulcers in diabetic patients. Method: This study consists of a systematic review of the specialized literature and meta-analysis of randomized clinical trials in the application of PRP in diabetic foot ulcers. For the elaboration of the research question, the acronym PICOS was used as well as in the orientation in the search strategies. The protocol for this study was registered in the PROSPERO database to register protocols for systematic reviews. The methodology proposed by the Cochrane Collaboration manual was adopted and the PRISMA checklist was used. The AMSTAR 2 tool was used to assess the quality of the review. Inclusion criteria were prospective, randomized clinical studies with no date limit. The forest plot graph was adopted for statistical analysis. Results: Of the 154 articles found in the search engine databases, 87 were excluded due to duplication, 58 because they did not meet the inclusion criteria and ended with 09 articles included. Two analyzes were performed, using the outcomes of treatment efficacy and reduction of ulcer size. Seven of the nine articles (408 patients) specified the outcome of treatment effectiveness, with a significant increase in cured patients. The other three articles (224 patients) specified a reduction in the size of the ulcer, being statistically significant in reducing the size of the ulcer. Conclusion: In conclusion, the sample analyzed from the systematic review of randomized clinical trials indicated that the use of platelet derivatives proved to be a good, safe and effective treatment option to accelerate the healing process of chronic foot ulcers in patients with diabetes mellitus, with no treatment-related complications. In view of the small sample of these studies, more randomized clinical studies are needed with a greater number of diabetic patients and patients with foot ulcers and with a greater follow-up.

MEMBROS DA BANCA:
Externo(a) à Instituição - ADEMARIO GALVAO SPINOLA - UFBA
Presidente - 286128 - GILDASIO DE CERQUEIRA DALTRO
Externo(a) à Instituição - JANE MARY DE MEDEIROS GUIMARÃES - UFSB
Interno(a) - 1348003 - MARIA LIGIA RANGEL SANTOS