Banca de DEFESA: GLEIDSON CARDOSO SPÍNOLA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : GLEIDSON CARDOSO SPÍNOLA
DATA : 08/10/2020
HORA: 14:00
LOCAL: Remotamente
TÍTULO:

Metformin for the treatment of diabetes mellitus in pregnancy: results of a retrospective study compared with current evidence.

PALAVRAS-CHAVES:

High-risk pregnancy. Gestational diabetes mellitus. Hypoglycemic agents. Metformin. Health technology assessment.

PÁGINAS: 118
GRANDE ÁREA: Ciências da Saúde
ÁREA: Saúde Coletiva
RESUMO:

Introduction: With the current criteria for the diagnosis of diabetes mellitus (DM) in pregnancy, it is estimated an increase from 7.6% to 18% of its prevalence in Brazil. The lack of glycemic control increases the risk of unfavorable maternal-fetal and neonatal outcomes. Oral hypoglycemic agents appear as a therapeutic alternative before insulin therapy when behavioral changes (diet and physical activity) are not successful and metformin emerges as a safe and effective drug in pregnancy. Objective: To trace the sociodemographic profile of pregnant women attended at Maternidade Climério de Oliveira (MCO), diagnosed with gestational diabetes mellitus (DMG) and type 2 pre-gestational diabetes (DM2), treated with metformin, observing the convergence of the main gestational complications and of maternal-fetal outcomes with current evidence from the literature. Method: Retrospective cross-sectional observational study involving diabetic pregnant women (DMG or DM2) who used metformin alone or associated with insulin. Discussion: Data from 58 pregnant women and telephone interviews were analyzed in order to compare different maternal-fetal outcomes with current evidence selected in a systematic literature review. Sociodemographic data evaluated: race, education level, income and place of residence. Maternal-fetal and neonatal outcomes analyzed: prematurity; macrosomia or newborns large for gestational age; admission to the Neonatal Intensive Care Unit; neonatal hypoglycemia; Apgar of 5 minutes (> 7); dystocia; frequency of cesarean sections; instrumental deliveries; failure to induce vaginal delivery; maternal-fetal metabolic disorder; body mass index (BMI) at delivery and hypertensive disease specific to pregnancy (DHEG). Relevant clinical variables discussed: age, parity, abortions and comorbidities. Conclusion: This research with extensive literature review showed that in the analyzed population, mostly black, in unfavorable socioeconomic and cultural conditions and without other studies on the use of metformin in pregnancy, the results converged with the current evidence in the literature. Additionally, it aims to collaborate with the decision making of the managers and clinical staff of the maternity hospital on the use of metformin; with the development of indicators related to DM in pregnancy and professional qualification for specific DM care. It also intends to promote effectiveness studies on the impact of the use of metformin in high-risk pregnant women with diabetes mellitus.

MEMBROS DA BANCA:
Presidente - 274.662.485-00 - JANE MARY DE MEDEIROS GUIMARÃES - UFSB
Externo ao Programa - 1993362 - LIDIA LIMA ARAGAO SAMPAIO
Externo ao Programa - 536.432.329-34 - MARIA CRISTINA DE CAMARGO FONSECA - UEFS
Externo à Instituição - ROSEANNE MONTARGIL ROCHA - UESC-BA