BIOTECHNOLOGICAL POTENTIAL OF FRESHWATER MITOSPORY FUNGI
metabolites, bioactivity, antimicrobial, aquatic hyphomycetes
: Fungi that occupy freshwater environments have been reported to produce metabolites with wide chemical diversity and a wide range of biological activities. Among the groups of fungi that occur in these environments are the mitosporic fungi, which consist of asexual states, mainly of ascomycetes and some basidiomycetes. Aquatic hyphomycetes are mitosporic fungi recognized mainly for their role in the decomposition of allochthonous leaf organic matter in lotic environments and for their ability to sporulate below the surface. The main objective of this work is to evaluate the biotechnological potential of freshwater mitosporic fungi. Chapter 1 is an integrative review on the metabolic production of aquatic hyphomycetes and its biotechnological applications. The results showed this group as important producers of several metabolites with applications in several sectors of industry, agriculture and health, mainly enzymes associated with the breakdown of lignocellulolytic compounds and with antimicrobial potential. Chapter 2 is an experimental work that aimed to evaluate the antimicrobial activity of four species of mitosporic fungi isolated in different streams associated with decomposing plant material. The fungi were grown in different culture media and their crude extracts were tested against nine bacterial and fungal pathogens using the broth microdilution technique. The fungi F. curvula, A. penicillioides and P. submersus strain 133057 inhibited most bacterial pathogens, but none showed antifungal activity. Strains of the same species collected from different environments and extracts from cultures in different culture media showed differences in terms of bioactivity, which are important aspects to be considered in the bioprospecting of antimicrobial activity