Banca de DEFESA: LUCAS MATHEUS GONÇALVES DE OLIVEIRA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : LUCAS MATHEUS GONÇALVES DE OLIVEIRA
DATA : 01/07/2019
HORA: 14:00
LOCAL: NUCLEO UNIVERSITARIO DE TELEMEDICINA/HUPES
TÍTULO:

Bifidobacteria and lactobacilli from the intestinal microbiota and its relation with clinical and immunological markers in Chronic Obstructive Pulmonary Disease

PALAVRAS-CHAVES:

COPD

Gut microbiota

Bifidobacteria

Lactobacilli

PÁGINAS: 30
GRANDE ÁREA: Ciências Biológicas
ÁREA: Bioquímica
RESUMO:

A number of studies contribute to the idea that the intestinal microbiota (IM) plays a role in the metabolic and immune regulation of the host. There is evidence that IM is involved in the control of secretion of hormones such as insulin through the release of GLP-1 and control of satiety by the modulation of PYY. In addition, MI is important for the development of Peyer's plaque and the immune system as a whole, especially in the early years of life. Among the diversity of MI, it is possible to highlight bacteria of the genus Lactobacillus and Bifidobacterium, which appear to exert immunoregulatory functions and are widely used as probiotics. Chronic Obstructive Pulmonary Disease (COPD) is a disease usually caused by inhalation of harmful particles and gases that cause prolonged damage to the airways and / or alveoli, thus impairing their physiological role and causing symptoms such as dyspnea, chronic cough and expectoration. Inhalation of toxic gases leads to an inflammatory process characterized by the systemic increase of molecules as acute phase proteins, in addition to IL-1, IL-6, IL-8, TNF and its receptors. Some studies have shown that the use of probiotics based on Lactobacillus sp. and Bifidobacterium sp. It can help in the general picture of the disease. However, the relationship between the levels of these bacteria in IM and COPD is not well elucidated. Therefore, this work aims to evaluate if there are changes in the levels of Lactobacillus sp. and Bifidobacterium sp. in patients with COPD and to correlate the levels of these bacteria with clinical and inflammatory markers.

MEMBROS DA BANCA:
Presidente - 1477723 - GYSELLE CHRYSTINA BACCAN
Externo ao Programa - 3079119 - NESTOR ADRIAN GUERRERO GUTIERREZ
Externo à Instituição - ANA MARIA CAETANO DE FARIA - UFMG