Banca de DEFESA: ALLYNE BAIA LEITE

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : ALLYNE BAIA LEITE
DATA : 28/05/2021
HORA: 14:00
LOCAL: Universidade Federal da Bahia - Instituto Multidisciplinar em Saúde/Campus Anísio Teixeira
TÍTULO:

High-intensity interval training (HIIT) is more effective than continuous aerobic exercise to reduce markers of the innate immune response in female rats with cisplatin-induced nephrotoxicity.

PALAVRAS-CHAVES:

Nephrotoxicity, cisplatin, exercise training, HIIT

PÁGINAS: 59
GRANDE ÁREA: Ciências Biológicas
ÁREA: Fisiologia
SUBÁREA: Fisiologia de Órgãos e Sistemas
ESPECIALIDADE: Fisiologia Renal
RESUMO:

Cisplatin (CP) is a chemotherapy widely used for treatment of several types of solid tumors, however the therapeutic regimens with this drug are often associated with several adverse effects, mainly nephrotoxicity. Some studies have shown protective effects of aerobic exercise training in the acute kidney injury (AKI), however the mechanisms underlying these effects are not fully understood. Furthermore, it is not yet known which intensity of aerobic exercise training is more effective in providing renoprotection, especially in females. Thus, the aim of this study was to compare the impact of preconditioning with high- intensity interval training (HIIT) with continuous training of low (LIT) and moderate (MIT) intensity on innate immunity markers in female rats with CP-induced acute kidney injury. For this, The rats were divided into five groups (n = 7): saline control and sedentary (C + S); CP and sedentary (CP + S); CP and LIT (CP + LIT); CP and MIT (CP + MIT) and CP and HIIT (CP + HIIT). The training intensity was determined by a maximum running test. At the end of training, AKI was induced by single dose of CP (5 mg/kg), and 7 days later they were euthanized. We evaluated renal function parameters (serum creatinine, glomerular filtration rate [GFR] and proteinuria), renal structure, macrophage tissue infiltration, immunolocalization of nuclear transcription factor kappa B (NF-κB), renal levels of tumor necrosis factor-alpha (TNF-α), interleukin 1β (IL-1β), and interleukin 6 (IL-6), and gene expression of monocyte chemoattractant protein-1 (MCP-1), toll-like receptor 4 (TLR4), and NF-κB in renal tissue. The results showed that, although both MIT and HIIT attenuated the degree of tissue damage, only HIIT was able to prevent changes in GFR and serum creatinine. The three training protocols were effective in attenuating increases in the expression of all inflammatory markers evaluated in this study, however this effect was more pronounced in HIIT. Similarly, the three training protocols provided equivalent increases in physical performance during the maximum run test at the end of the 8th week of exercise training. However, the data shows that at the end of the 4th week, only HIIT was able to provide an increase in physical performance in relation to sedentary groups. Taken together, the data demonstrate that although the three training protocols provided renoprotective actions, the effects were more pronounced in HIIT, suggesting that HIIT was more effective in mitigating cisplatin-induced AKI in this experimental model, in part by modulation of important markers of the innate immune response.

MEMBROS DA BANCA:
Presidente - 2312625 - LILIANY SOUZA DE BRITO AMARAL
Interno(a) - 1552395 - TELMA DE JESUS SOARES
Externo(a) ao Programa - 2418292 - SAMIRA ITANA DE SOUZA