Banca de DEFESA: LORENA ALVES DE OLIVEIRA SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : LORENA ALVES DE OLIVEIRA SILVA
DATA : 05/12/2019
HORA: 14:00
LOCAL: Instituto Multidisciplinar em Saúde
TÍTULO:

Development of nanodisperse systems containing Carbamide peroxide for dental whitening

PALAVRAS-CHAVES:

Dental whitening; carbamide peroxide; microemulsion; validation of analytical method

PÁGINAS: 95
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

Growth in the field of aesthetic dentistry has increased, as a result of the requirement in the aesthetic pattern of smile. A healthy and beautiful smile improves self-image and confidence, is directly associated with searching for whiter teeth, which makes dental whitening a requested procedure today. Whitening consists a result of a complex physical and chemical interaction between the tooth and the stain causative agent. When thinking about developing new products, nanotechnology has been pointed out as the technological revolution, which has aroused a huge interest in the scientific community over the past few decades, being one of the main focuses of development and innovation in all countries. Microemulsions (EMs) are nanotechnological, thermodynamically stable, isotropic, dispersed systems consisting of two imiscible liquids. The validation of an analytical method, in the quality control of pharmaceutical products, is to demonstrate that the method is appropriate for a given purpose, that is, the quantitative determination of drugs. In this work, the stability of nanotechnological systems containing carbamide peroxide 16% for tooth whitener was characterized and evaluated, with permeation potential in the dentin canaliles in order to optimize the bleaching process. The selected formulation, from the phase diagram, carbamide peroxide 16% was incorporated, and then characterized (optical microscopy, pH, particle size, polydispersivity index, zeta potential,conductivity). The formulation also submitted to the study of preliminary and accelerated stability. Validated the method for quantifying carbamide peroxide, according to RDC 166 – ANVISA. The product containing Carbamide Peroxide 16% obtained pH values of 5.86 ± 0.05; zeta potential -6.38 ± 0.37mV; droplet size 22.52 ± 0.37nm; Polydispersivity index 0.164±0.02 and Conductivity 0.1063±,001μs/cm. The rheological profile of the analyzed samples presented with thixotropic behavior. The product is stable.

MEMBROS DA BANCA:
Externo ao Programa - 1553664 - ADRIANO MAIA DOS SANTOS
Externo ao Programa - 2585200 - ANGELICA FERRAZ GOMES
Externo à Instituição - MATEUS FREIRE LEITE