Banca de DEFESA: ANA LUCIA VIEIRA DE FREITAS BORJA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
DISCENTE : ANA LUCIA VIEIRA DE FREITAS BORJA
DATA : 21/12/2020
HORA: 14:00
LOCAL: PLATAFORMA GOOGLE MEET
TÍTULO:

Auditory cortical evoked potential of children with presumed exposure to the Zika virus during pregnancy.

PALAVRAS-CHAVES:

Congenital zika virus infection. Evoked potential P300. Neurodevelopmental disorders. Auditory cortex

PÁGINAS: 87
GRANDE ÁREA: Ciências da Saúde
ÁREA: Fonoaudiologia
RESUMO:

Recent studies have suggested the presence of neurodevelopmental impairments, especially for cognitive and language domains, in normocephalic children exposed to ZIKV during gestational period. The development of speech and language depends on the integrity of both peripheral and central auditory system. Undetected hearing disorders in childhood, either congenital or acquired, can significantly affect communication and cognition and also interfere with the child's neurodevelopment. Objective: To compare latency and amplitude of auditory cortical evoked potentials to neurodevelopment, gestational information and clinical and sociodemographic data for children supposedly exposed to zika virus. Methodology: Cross-sectional prospective exploratory study based on a representative simple random sample of the observational cohort study International observational prospective cohort study of zika in children and pregnant women (ZIP study), approved by the Research Ethics Committee CAEE No 56673616.3.1001.5269. The study population consisted of 237 hearing children supposedly exposed to ZIKV and not. The average age was 15 +/- 2,1 months. Previous hearing tests that presented otoacoustic emissions and short latency evoked potential confirmed inclusion criteria. To assess the cortical auditory potential, 150 tone burst stimuli presented monoaural, rate of 1.2 stimuli per second, which differed in frequency (standard stimulus: 1000 Hz; rare stimulus: 2000 Hz). To assess neurodevelopment, the Bayley Scales of Infant Development was applied. Results: The cortical potential were in all children and presented substantial difference of average latencies and level of statistical significance for P1 and N1 in children supposedly exposed to zika virus. The averages of P1-N1-P2-N2 latencies were higher in the group at risk for neurodevelopment in all assessed domains. The cognitive and expressive language domains were statistically significant for the mean latencies of all cortical potential structures. There was also an association between risk classification and sex for cognitive (p = 0.025) and language (p = 0.050) domains and a performance advantage for girls. The mean of the raw scores were also higher for females in all Bayley domains, with statistical significance for both receptive (p = 0.008) and expressive (p = 0.041) language. Conclusion: Children supposedly exposed to zika virus presented average latencies higher for P1-N1 cortical responses, which suggests a worse processing of the acoustic signal in relation to unexposed children. Supposed exposure to zika virus during pregnancy may be associated with higher latencies of P1-N1 complex and lower scores for neurodevelopmental domains, which suggests both cortical auditory and neurodevelopment impairments, especially for expressive language.

MEMBROS DA BANCA:
Externo à Instituição - CONCEICAO SILVA OLIVEIRA - UNEB
Externo à Instituição - DEOLINDA MARIA FELIN SCALABRIN - Fiocruz-Ba
Externo à Instituição - JANAYNA DE AGUIAR TRENCH - UFS
Externo à Instituição - MARIA DA GLÓRIA CANTO DE SOUSA - UNEB
Presidente - 7282322 - ROBERTO PAULO CORREIA DE ARAUJO