Banca de DEFESA: JAMILLE DA CONCEIÇÃO SOUZA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : JAMILLE DA CONCEIÇÃO SOUZA
DATE: 17/08/2022
TIME: 09:30
LOCAL: Online
TITLE:

DHA and EPA in sickle cell disease and quality of life: a qualitative systematic review.

KEY WORDS:

key-words: n-3 fatty acids. PUFA n-3. HbSS disease. Quality of life.

PAGES: 85
BIG AREA: Ciências Agrárias
AREA: Ciência e Tecnologia de Alimentos
SUBÁREA: Ciência de Alimentos
SPECIALTY: Valor Nutritivo de Alimentos
SUMMARY:

The present study sought to analyze the therapeutic potential of omega-3 in sickle cell diseases with a focus on sickle cell anemia. Sickle cell anemia is among the most prevalent hemoglobinopathies in the world and is therefore a global public health issue. Also known as hemoglobin S disease, sickle cell anemia comes from a genetic modification on chromosome eleven, in which the replacement of the nitrogenous base adenine by thymine results in the replacement of the glutamic amino acid by valine, originating hemoglobin S. This modification is responsible for triggering complications at the systemic level, including: vaso-occlusive crises, hemolysis, chronic anemia, infarcts at the micro and macrovascular levels and chronic inflammatory state. The n-3 is a polyunsaturated fatty acid, with an important anti-inflammatory action well delineated in the literature, its benefits in terms of cardiovascular health and diseases related to inflammation are well highlighted, in this context, it is suggested that n-3 has important therapeutic potential for people with sickle cell disease. Thus, the present study is structured into two chapters, chapter one, the theoretical framework and chapter two, the manuscript with a qualitative systematic review (RSQ) outline, has the general objective: to highlight the therapeutic potential of n-3 and its contribution to the quality of life of people with sickle cell disease. This protocol has been designed in accordance with the preferred reporting item guidelines for systematic review (qualitative and quantitative) and protocol checklist. Registered in the International Prospective Registry of Systematic Assessments under registration ID: CRD42020221207. The search strategy used was PICOS. The search was performed by combining the descriptors, using the terms sickle cell anemia and n-3, which were obtained from the Virtual Health Library, DeCS/MeSH. The databases used were: Scopus, PubMed, ScienceDirect, Web of Science and Virtual Health Library. The assessment of the risk of bias in the primary studies was carried out using the Cochrane Risk of Bias tool for Randomized Controlled Trials and the assessment of the set of the quality of evidence performed using the Grading of Recommendatons Assessment, Development and Evaluaton tool. From the 177 records identified, seven were selected for data collection. The main outcome of this study is based on the contribution of an oral supplementation of n-3 DHA and EPA to improve the quality of life of people with sickle cell disease. For this main outcome, the items analyzed were: less activation of pro-inflammatory substances linoleic acid, nuclear factor KappaB, arachidonic acid, leukocytes and integrins; reduced activities of antioxidant enzymes, glutathione peroxidase, copper and zinc dependent superoxide dismutase, and phosphatidic acid phosphates; higher concentrations of DHA and EPA in erythrocyte membranes; better hemostatic pattern with plasma reduction of prothrombin and D-dimer, reduction of vaso-occlusive crises, reduction of pain episodes, hospitalization and improvement in school attendance, such effects possibly related to reduced hemolysis and prothrombotic activity. Thus, with the improvement of such clinical signs, the reflex for the patient is a significant improvement in their quality of life condition, and the study aims to support the emergence and updating of new public policies for people with sickle cell disease.

BANKING MEMBERS:
Presidente - 1490663 - RICARDO DAVID COUTO
Interna - 3170723 - CAMILA DUARTE FERREIRA RIBEIRO
Externa ao Programa - 1066101 - JAIRZA MARIA BARRETO MEDEIROS