Banca de DEFESA: MARIANE DOS SANTOS GONÇALVES

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : MARIANE DOS SANTOS GONÇALVES
DATA : 24/08/2020
HORA: 14:00
LOCAL: Salvador
TÍTULO:

Therapeutic effect of the green tea on liver changes resulting from consumption of a high-fat diet

PALAVRAS-CHAVES:

Camellia sinensis, catechin, NAFLD, liver function, hepatic steatosis, transaminases.

PÁGINAS: 48
GRANDE ÁREA: Ciências da Saúde
ÁREA: Nutrição
SUBÁREA: Bioquímica da Nutrição
RESUMO:

Food choices are directly related to the population health. The increase in the consumption of calories and saturated fats, together with the low consumption of fruits and vegetables, favors the emergence of obesity and numerous diseases related to it, such as, for example, Non-Alcoholic Fatty Liver Disease (NAFLD). Therefore, new strategies must be analyzed to treat this disease. Green tea is rich in caffeine and catechins, and because of that its therapeutic properties have been investigated. The study aims is to evaluate the effect of the green tea infusion on the metabolic and hepatic modifications of mice fed a high-fat diet. Male C57BL/6 mice, aged forty to sixty days, were randomly allocated into 4 groups: control (C), control + green tea (CGT), high-fat diet (HF) and high-fat diet + green tea (HFGT). The mice following parameters were evaluated from all experimental groups: BMI, by every two weeks; fasting glycemia (i.e. at the start and final experiment); response to the OGTT, at 15 weeks; and ITT, at 16 weeks; and biochemical tests, at 16 weeks. The mice fed the HFD when compared to those fed the C diet showed an increase of final body weight (p ≤ 0.001), relative liver weight (p ≤ 0.001), fasting glycemia (p ≤ 0.001), HDL cholesterol, and ALT (P ≤ 0.05).  Moreover, the HFD group showed other disturbances such as glucose intolerance (p ≤ 0.05), and peripheral insulin resistance (p ≤ 0.001) evidenced by OGTT and ITT AUC values. Further, the effect of green tea on the serum lipid profile was evaluated on the HFDGT group compared to the HFD group. The HFDGT group showed a decrease of final body weight (p ≤ 0.05), fasting glycemia (p ≤ 0.01), HDL cholesterol (p ≤ 0.001), total cholesterol (p ≤ 0.001),  and ALT (p ≤ 0.05) when compared to the HFD group.  On the HFDGT group, green tea was effective in restoring glucose intolerance (p ≤ 0.05) but did not have a significant impact on ITT values.  The overall metabolic responses to the green tea infusion proved to be desirable. Green tea contributed to glucose metabolism and seems to improve liver function

MEMBROS DA BANCA:
Interno - 2091662 - EDERLAN DE SOUZA FERREIRA
Presidente - 1490663 - RICARDO DAVID COUTO
Externo à Instituição - THAÍS SOUZA PASSOS - UFRN