Banca de DEFESA: CAROLINE VIEIRA GONÇALVES

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : CAROLINE VIEIRA GONÇALVES
DATA : 11/06/2021
HORA: 09:00
LOCAL: Instituto Multidisciplinar em Saúde
TÍTULO:

Inflammaging and adipose tissue:  New insights in diabetic and hipertensive elderly men

PALAVRAS-CHAVES:

Elderly, Type 2 Diabetes mellitus, Systemic arterial hypertension, Overweight.

PÁGINAS: 104
GRANDE ÁREA: Ciências Biológicas
ÁREA: Fisiologia
SUBÁREA: Fisiologia Geral
RESUMO:

INTRODUCTION/OBJECTIVE: The combination of increasing metabolic risks and an aging population will likely continue to drive the growing trends in Chronic Non-Communicable Diseases (NCDs) globally. Systemic arterial hypertension (SAH) and type 2 diabetes mellitus (DM2) are highly relevant NCDs due to the high mortality in the elderly population. Despite the different organs and systems involved has a common risk factor: clinically inflammation silence low-grade. This inflammation has as its principal factor the excess of adipose tissue. In this sense, this work aimed at the expanded study of anthropometric, biochemical, and inflammatory markers of elderly with SAH and DM2. METHODS: The study involved the evaluation of 49 men aged 60-80 years with SAH and DM2. The divided groups according to BMI into eutrophic elderly (EE, n = 24) or overweight elderly (OE, n = 25). Bioimpedance analysis was used to collect anthropometric data. Blood collection was performed to analyze inflammatory and biochemical data. The serum obtained was evaluated by enzymatic assays. RESULTS: Although most of the elderly undergo drug treatment for diabetes and hypertension, they did not have their blood glucose and blood pressure levels controlled. Overweight elderly had a higher glycemic index (p = 0.0201). All the anthropometric data analyzed showed statistically significant differences when compared between groups. There was an increase in most anthropometric markers in overweight elderly. In contrast, in this same group, there was a decrease in the values of lean mass (p <0.0001), bone mass (p <0.0001), water (p <0.0001) and basal metabolism (p = 0.001). Overweight elderly had higher averages for all analyzed inflammatory cytokines. These include: IL-17A (p = 0.0154), IL-1β (p = 0.0376), INF-y (p = 0.0442) and TNF-α (p = 0.0064). In contrast, there was a decrease in the anti-inflammatory cytokine IL-10 (p = 0.0367) in overweight elderly. Also, we observed an increase in the IL-10/IL-17A ratio in eutrophic elderly about overweight elderly. The correlation patterns for biochemical, inflammatory, and body composition variables are different between groups. The correlations are more intense in the eutrophic elderly, especially concerning inflammatory variables and the fat mass variable. CONCLUSION: Although the overweight elderly has an increase in inflammatory parameters, the intensity of their correlations with anthropometric and biochemical parameters are less evident. Also, we found that the pattern of influence of these cytokines is quite different about body composition.

MEMBROS DA BANCA:
Presidente - 2497915 - ROBSON AMARO AUGUSTO DA SILVA
Interno(a) - 2312625 - LILIANY SOUZA DE BRITO AMARAL
Externo(a) à Instituição - DENISAR PALMITO DOS SANTOS