Banca de DEFESA: MARIA POLIANA LEITE GALANTINI

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : MARIA POLIANA LEITE GALANTINI
DATA : 31/01/2020
HORA: 14:00
LOCAL: Instituto Multidisciplinar em Saúde / UFBA
TÍTULO:

The sweet fuel of inflammation: new looks in the complex web that interconnects diabetes and hypertension

PALAVRAS-CHAVES:

DCNT. Hypertension. Diabetes. Biomarkers. Inflammation. Hyperglycemia. Physical activity

PÁGINAS: 71
GRANDE ÁREA: Ciências Biológicas
ÁREA: Imunologia
SUBÁREA: Imunologia Aplicada
RESUMO:

Noncommunicable chronic diseases (NCDs) account for about 70% of all deaths worldwide. In this scenario, systemic arterial hypertension (SAH) and type 2 diabetes mellitus (DM2) are diseases that have several aspects in common. These biomarkers provide an understanding of disease processes and can benefit early detection, treatment and management. Thus, the aim of this study was to evaluate serum biomarker concentrations in serum of patients with different severities of DM2 and SAH as well as to analyze the correlations between interleukins and disease severity. Initially, patients previously diagnosed with DM2 and hypertension were stratified into different degrees of disease, aiming to detect the factors that most influence the complications of the aforementioned diseases. The groups were divided into low risk (1), moderate risk (2), high risk (2), very high risk (4), according to the European Society of Cardiology, which correlates blood pressure values with the presence of of risk factors. To perform this work, volunteers were recruited for pressure measurement and body composition analysis was performed through bioimpedance. Blood was collected from these patients for biochemical measurements and ELISA to detect serum concentrations of cytokines IL-17, IL-1β, IFN-γ, TNF-α and IL-10. Statistical analyzes were performed using the Kruskal-Wallis test, and correlations were analyzed using the R Studio software. We observed that the higher the severity, the higher the serum concentration of proinflammatory cytokines, however, no significant difference was observed between sexes or climacteric period. Strong positive correlations were found between IL-17, IL-1β and IFN-γ of the low risk group, and these correlations are lost as the risk group increases. These findings suggest that inflammation is present contributing to the worsening of hypertension and DM2. Through Bayesian analyzes we found hyperglycemia playing a central role in modulating the proinflammatory state. This state can be changed with the practice of physical activity, confirming its beneficial and protective effect. This is the first paper that shows the complex interaction between different biomarkers in DM2 and SAH, especially hyperglycemia as inflammation inducer, and how the interaction of these markers increases disease severity.

MEMBROS DA BANCA:
Interno - 1112111 - AMELIA CRISTINA MENDES DE MAGALHAES GUSMAO
Externo ao Programa - 1552287 - LAIZE TOMAZI
Presidente - 2497915 - ROBSON AMARO AUGUSTO DA SILVA