Banca de DEFESA: GABRIELLA DE ALMEIDA OLIVEIRA EVANGELISTA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : GABRIELLA DE ALMEIDA OLIVEIRA EVANGELISTA
DATA : 11/12/2019
HORA: 14:00
LOCAL: Salas Especiais - Ophelia Gaudenzi 3º andar
TÍTULO:

DIAGNOSTIC OF ZIKA AND CHIKUNGUNYA ARBOVIRUS IN MENINGOENCEFALITES, IN SALVADOR, BAHIA, BRAZIL

PALAVRAS-CHAVES:

Meningoencephalitis. Infection. Zika, Cikungunya, Virus

PÁGINAS: 100
GRANDE ÁREA: Outra
ÁREA: Tecnologia e Inovação
RESUMO:

Chikungunya (CHIKV) and Zika (ZIKV) viruses have recently been presented as growing causes of neurological diseases. They have spread widely around the world, producing various infections. Although with considerable rarity, infections with these viruses lead to central nervous system (CNS) disease with acute clinical manifestations, such as headache and neck stiffness, whose symptoms are suggestive for meningitis; For cases that present with convulsions, it indicates the occurrence of encephalitis; limb motor dysfunction and sphincter dysfunction may be related to myelitis and Guillain Barré Syndrome (GBS). The objective of this study is to investigate the presence of CHIKV and ZIKV in cerebrospinal fluid (CSF) of patients with meningoencephalitis of viral origin, not specified in the population of the state of Bahia. Samples from 149 patients underwent CSF physicochemical analysis and molecular diagnosis by real-time RT-PCR (RT-qPCR). Eighteen patients were positive for ZIKV and two for CHIKV. The patients presented several clinical manifestations, such as photophobia, headache, altered mental state, seizures or focal neurological signs. Therefore, the most frequent manifestation in patients under 1 year of age, in the percentage of 20%, was viral meningitis. Viral meningitis and headache were observed in 30% of the cases aged 1 to 15 years. In the remaining cases (50%) the clinical picture was more nonspecific (fever and mental confusion). It was concluded that meningoencephalitis of viral etiology in the state of Bahia may be related to the presence of ZIKV and CHIKV in the CNS.

MEMBROS DA BANCA:
Interno - 287168 - LILIA FERREIRA DE MOURA COSTA
Externo à Instituição - REJANE HUGHES CARVALHO
Presidente - 1311777 - SILVIA INES SARDI