Banca de DEFESA: BEATRIZ NEVES DA ROCHA PEREIRA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : BEATRIZ NEVES DA ROCHA PEREIRA
DATE: 21/11/2023
TIME: 09:00
LOCAL: na Plataforma Zoom ( https://zoom.us/j/91496312921?pwd=emZ2dGdMbzFZa0hWMUFpM3F3ZFJlZz09 )
TITLE:

CLINICAL VARIABLES THAT INTERFERE WITH PLATELET CONCENTRATION OF PLATELET-RICH PLASMA (PRP)

KEY WORDS:

Platelet-rich plasma; Immune profile; Platelet concentration.

PAGES: 61
BIG AREA: Outra
AREA: Multidisciplinar
SUMMARY:

Tissue regeneration is studied a lot within the scientific community and therapeutic options for
this, minimally invasive, gain prominence, as they involve much lower intra and postoperative
invasive procedures for the patient compared to surgical procedures of great extension. To this
end, the autologous biological compound platelet-rich plasma (PRP) becomes a path towards
the objective of regenerating an injury at the rate that it delivers to the patient a
supraphysiological concentration of cellular mediators found within platelets, active in the
inflammatory process, including growth factors and cytokines. The composition of the
bioproduct will be influenced by the baseline health of the individual for whom the PRP is
being prepared, consequently affecting the development of the therapy. The present work
explores some clinical variables that may affect the platelet concentration of the bioproduct by
analyzing them using the Poisson distribution, considering studying the relationship between
the variable D and PRL with the variables: X1 = group (1-presence of osteoarthritis; 0- no
presence of osteoarthritis); X2 = gender (1- masculine; 0- feminine); X3 = age (1- under 60
years old; 0- over 60 years old); X4 = smoker (1-yes; 0-no); X5 = alcohol consumption (1-yes;
0-no); X6 = Frequency of non-steroid anti-inflammatory consumption (NSAIDs) (1- diary; 2-
casually; 3- don't use); X7 = presence of self-reported diabetes (1-yes; 0-no); X8 = presence of
self-reported hypertension (1-yes; 0-no); X9 = presence of osteoarticular and/or
musculoskeletal conditions (1-yes; 0-no). With the exception of the variable gender and
frequency of occasional NSAID consumption, the variables had a significant impact on platelet
concentration and difference in platelet-rich plasma. Therefore, when determining the
production of the biomaterial, it is necessary to give importance and consider the clinical
aspects of the patient's health status, observing and analyzing the variables portrayed, since this
immunological profile of the patient will also be exposed in the platelet concentrate produced
and this will interfere with the therapeutic quality and the desired recovery process.

COMMITTEE MEMBERS:
Presidente - 286128 - GILDASIO DE CERQUEIRA DALTRO
Interno - 664720 - ANTONIO FERREIRA DA SILVA
Externa à Instituição - VALERIA LIMA BOTELHO