Banca de DEFESA: MARÍLIA CARNEIRO DE ARAÚJO MACHADO

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
DISCENTE : MARÍLIA CARNEIRO DE ARAÚJO MACHADO
DATA : 25/03/2019
HORA: 14:00
LOCAL: Congregação EMEVZ-UFBA
TÍTULO:

Influence of cyclophosphamide and pharmacokinetics of carboplatin on female dogs with mammary carcinomas and degree of adverse effects of chemotherapy

PALAVRAS-CHAVES:

Adjuvant treatment, chemotherapy, dogs, liquid chromatography, mammary neoplasia.

PÁGINAS: 80
GRANDE ÁREA: Ciências Agrárias
ÁREA: Medicina Veterinária
SUBÁREA: Patologia Animal
ESPECIALIDADE: Anatomia Patologia Animal
RESUMO:

There is increasing number of studies that seek new therapeutic approaches for mammary neoplasia in female dogs. In this context, the objective of this study was to evaluate the influence of cyclophosphamide on the pharmacokinetics (PK) of carboplatin in female dogs with mammary carcinomas, as well as to verify possible side effects associated with the treatment. Sixteen female dogs, all with histopathological diagnosis of mammary carcinomas, were divided into two experimental groups: Group 1 consisted of animals treated with carboplatin alone in the conventional chemotherapy modality (n = 8) and Group 2 animals treated with carboplatin as conventional chemotherapy associated with cyclophosphamide in metronomic regimen (n = 8). All animals were submitted to clinical evaluation, mastectomy, chemotherapy with carboplatin and pharmacokinetic analysis, as well as the evaluation of survival rate and adverse effect score periodically. The results showed that although there was a significant difference in carboplatin pharmacokinetic parameters (volume of distribution, half-life, clearance and area under the curve), there was a significant difference in the reduction of hematological values for the dogs treated with carboplatin + cyclophosphamide, however these were not sufficient to alter the degree of adverse effects caused by this type of treatment. These results evaluated together indicate that the association between carboplatin and cyclophosphamide represents a viable alternative for the adjuvant treatment of female dogs with mammary carcinomas, since it contributes to the increase in the survival rate of these patients.

MEMBROS DA BANCA:
Presidente - 1489010 - ALESSANDRA ESTRELA DA SILVA LIMA
Interno - 1283878 - STELLA MARIA BARROUIN MELO
Externo ao Programa - 1012812 - FRANCINE JOHANSSON AZEREDO
Externo à Instituição - GEOVANNI DANTAS CASSALI - UFMG
Externo à Instituição - KARINE ARAUJO DAMASCENO