Banca de DEFESA: DANIELA MORENO CORTES

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : DANIELA MORENO CORTES
DATA : 27/08/2021
HORA: 14:00
LOCAL: online sala virtual google meet
TÍTULO:

Hand grip strength in patients with advanced chronic liver disease: cutoff values associated with survival

 

 

 

PALAVRAS-CHAVES:

Keywords: Handgrip strength; Reference values; Chronic liver disease; Survival.

PÁGINAS: 55
GRANDE ÁREA: Ciências da Saúde
ÁREA: Nutrição
SUBÁREA: Desnutrição e Desenvolvimento Fisiológico
RESUMO:

 

 Introduction: The association of inadequate nutritional status with unfavourable clinical outcomes reinforces the need for reproducible, reliable, and affordable tools for nutritional assessment for patients with advanced chronic liver disease (ACLD). Handgrip strength (HGS) is an important biomarker for nutritional assessment and diagnosis of sarcopenia. Only very few studies have defined cutoff values for the prediction of adverse clinical results in ACLD patients. The aim of this study was to identify HGS cutoff values in ACLD patients, and to assess their association for predicting survival 12 months forward. Method: This prospective observational study recruited patients with compensated and decompensated ACLD, followed for 12 months after the first outpatient visit or hospital discharge. HGS cutoff values was obtained using a Jamar™ dynamometer. Results were categorized considering the physiological muscle strength variation related to sex and age. Results: Cutoff values were 42 and 19 kg for male and female adults, respectively, and 28 and 17 kg for male and female elderly, respectively. Twenty-four % (n=67) of patients had died by the end of the 12-month follow-up, 80.6% of those were identified with inadequate HGS. Patients who did not survive the follow-up period presented a higher prevalence of moderate or severe malnutrition, decompensated ACLD and lower HGS. Conclusion: Inadequate HGS was identified as an independent predictor of survival in comparison to commonly employed prognostic indicators of ACLD. HGS scores lower than the cutoff points were significantly associated with mortality within 12 months. Such association was maintained even after adjustments for severity stages of liver disease at the beginning of the follow-up.

MEMBROS DA BANCA:
Presidente - 1107819 - ROSANGELA PASSOS DE JESUS
Interna - 4349788 - ANNA KARLA CARNEIRO RORIZ LOPES DE SOUZA
Interna - 1066101 - JAIRZA MARIA BARRETO MEDEIROS
Externa à Instituição - Lucilene Rezende Anastácio