Banca de DEFESA: DJANE DA ANUNCIAÇÃO DO ESPÍRITO SANTO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : DJANE DA ANUNCIAÇÃO DO ESPÍRITO SANTO
DATA : 07/06/2019
HORA: 14:00
LOCAL: Escola de Enfermagem - Sala 7.
TÍTULO:

Aortic histomorphometry and cardiometabolic  indicators risk  to the rats exposed  the hyperlipidic diet during perinatal period and after weaning.

PALAVRAS-CHAVES:

 hyperlipidic diet, metabolic programming, cardiac histomorphometry, rats.

PÁGINAS: 42
GRANDE ÁREA: Ciências da Saúde
ÁREA: Nutrição
RESUMO:

Introduction: Complications observed in the cardiovascular system with consequent cardiac remodeling associated with inflammatory conditions and changes in lipid profile became an important contributor to early CVD mortality. In this context, the identification of risk factors associated with cardiovascular diseases (CVD) favors the improvement of strategies for the prevention and reduction of complications caused by CVD. Therefore, the objective of this study was to evaluate the effects of exposure to a hyperlipidic diet during the perinatal period and after weaning on indicators of cardiometabolic risk and aortic histomorphometry in descending rats.

Methods: Female Wistar rats were separated into two groups and fed a standard diet (4% lipid) or a hyperlipid diet (23% lipid) during gestation and lactation. The offspring were divided into four groups: CC group (n = 6), CH group (n = 6), HH (n = 6) and HC group (n = 6). At 60 days of age, the biochemical and histomorfometric analyzes of the aortic artery were performed. Two-way ANOVA was used in the statistical analysis, followed by the Turkey’s test. The significance level adopted was 5%, in all cases.

Results: In the analysis of the cardiometabolic risk indicators, the CH group (2.27 ± 0.35mg/dl) showed a significant difference for the Castelli I index compared to the CC (1.02 ± 0.19 mg/dl), HC (1, 76 ± 0.88 mg/dl) and HH (1.76 ± 0.88 mg/dl) p < 0.01. In the evaluation of the other indicators there was no difference between the groups. The thickness of the intima and middle layers of the aortic artery of the CH groups (43.47 ± 8.33 µm) and HH (43.94 ± 7.30 µm) had higher values compared to the CC group (30.40 ± 5.40 µm ). The HH group also presented a higher thickness compared to the HC group (33, 73 ± 5.68 µm) p < 0.01. The thickness of the elastic lamellae of the aorta of the HH group (3.08 ± 0.98 µm) presented a larger diameter when compared to the groups HC (2.00 ± 0.29 µm) and CC (1.84 ± 0.23 µm) p < 0.001 . In the elastic lamellar count, the CH (6.09 ± 1.22 µm) and HH (5.73 ± 0.64 µm) groups had a higher number compared to the CC (4.24 ± .50 µm) and HC ( 4.18 ± 0.69 µm) p < 0.01.

Conclusion: Exposure to a hyperlipidic diet increased the risk for developing cardiometabolic complications in addition to altering the histomorphometry of the aortic artery of young rats.

MEMBROS DA BANCA:
Interno - 414993 - GILSON TELES BOAVENTURA
Externo ao Programa - 1490663 - RICARDO DAVID COUTO
Externo à Instituição - Carlos Alberto Soares da Costa - UFRB