Banca de DEFESA: CLAUDINEIA ALMEIDA DE SOUZA
Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.DISCENTE : CLAUDINEIA ALMEIDA DE SOUZA
DATA : 24/05/2019
HORA: 16:00
LOCAL: Sala B - 1o andar do HUPES
TÍTULO:
EFFECTS OF PROBIOTIC, PREBIOTIC OR SYMBIOTIC SUPPLEMENTATION ON INTESTINAL MICROBIOTY IN PATIENTS WITH NON ALCOHOLIC FATTY DISEASE: A SYSTEMATIC REVIEW AND METHANALYSIS
PALAVRAS-CHAVES:
Nonalcoholic fatty liver disease, probiotics, prebiotics, symbiotics, gastrointestinal microbioma
PÁGINAS: 75
GRANDE ÁREA: Ciências da Saúde
ÁREA: Nutrição
RESUMO:
Among the mechanisms that may predispose non-alcoholic fatty liver disease (NAFLD), the intestinal microbiota has been the subject of intense research. In an attempt to modulate the intestinal microbiota, the use of probiotic, prebiotic or symbiotic supplements has been a common recommendation in clinical practice. Thus, the objective of this study is to systematically review data from the scientific literature on the characteristics of the intestinal microbiota after supplementation with probiotics, prebiotics or symbiotics in individuals with NAFLD. Methods: This is a systematic review developed in accordance with the PRISMA (Preferred reporting items for Systematic Reviews and Meta-Analyzes), whose protocol was submitted to Prospero (International prospective register of systematic reviews) as a systematic review and meta-analysis. Initially, two authors independently conducted the search for articles in the Medline databases via PubMed, Web of Science, Embase, Scopus, Lilacs, and the Ovid platform for gray literature research in April 2019. The The present study was carried out in accordance with the acronym PICO (Population: adults with diagnosis of NAFLD), and the analysis of probiotics, prebiotics and symbiotics. of intestinal permeability or bacterial overgrowth in the small intestine (SIBO) or collection of faecal sample or aspiration of the small intestine with quantitative count of bacteria). For the search in the databases, the terms for population and intervention were used. Initially titles and abstracts were read to exclude irrelevant articles. Subsequently the selected articles were read in full and evaluated according to the eligibility criteria. Reference lists of selected articles and thematic reviews were also searched. The articles included were read in full and the information contained therein was recorded in a standardized worksheet. The risk assessment of bias was in accordance with the Cochrane Collaboration criteria. Subsequently the results were inserted into the Review Manager 5.3 tool to create figures that could summarize the bias risk judgment of the included clinical trials. Results: A total of 3,324 references were identified through the electronic database search. Of these, 1,556 articles were excluded after removal of duplicates and 1,728 were excluded after reading the title and abstract. A total of 40 papers were read. After reading in full, only 4 articles were included in this systematic review. The methods used to characterize the intestinal microbiota were indirect from bacterial counts in fecal samples, as well as intestinal permeability evaluation from urinary lactulose / mannitol excretion and exhaled hydrogen test for SIBO evaluation. Most of the studies used symbiotic supplementation associated with dietary changes. Two studies showed that after intervention there were beneficial changes in the intestinal microbiota pattern and in the other two studies, such changes were not observed. All the studies presented a high risk of bias, with the majority having a small sample size. Conclusion: In this systematic review, in addition to the poor quality of the studies, the results were contradictory. Thus, it is not possible to affirm the effects of probiotic or symbiotic supplementation on the intestinal microbiota in patients with NAFLD.
MEMBROS DA BANCA:
Interno - 3315542 - RAQUEL ROCHA DOS SANTOS
Externo ao Programa - 2445131 - ANTONIO RICARDO CARDIA FERRAZ DE ANDRADE
Externo ao Programa - 1164303 - CAROLINA SANTOS MELLO