Banca de DEFESA: MARCIA UZÊDA PEREIRA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : MARCIA UZÊDA PEREIRA
DATE: 20/06/2023
TIME: 15:00
LOCAL: https://meet.google.com/vdp-tctn-ycf
TITLE:

Onion peel (Allium Cepa L) powder and high-fat diet intake: effects on adipose tissue in rats.

KEY WORDS:

 Allium Cepa L, high-fat diet, white adipose tissue, brown adipose tissue, metabolic programming.

PAGES: 87
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

 

Introduction: Excess adipose tissue causes metabolic disorders. Phenolic compounds, such as onion skin powder, can alleviate adipose tissue dysfunction. Objective: To investigate the effects of supplementation with onion skin powder (Allium Cepa L) on murinometric parameters and adipose tissue histomorphometry in rats submitted to a high-fat diet during pregnancy, lactation and post-weaning. In addition, to study in the literature the effects of quercetin on adipose tissue. Methodology: The study was divided into two stages. In the first one, a systematic review was carried out in the databases: Embase, Pubmed, Web of Science, Scopus and Science Direct. In the second stage, an experimental study was carried out in rats. The animals were divided into three groups: Control/Control (CC, n=8), Hyperlipidic/Hyperlipidic (HH, n=7) and Hyperlipidic/ Hyperlipidic + onion peel powder (HHOP, n=8). body weight gain, Lee index, waist circumference and caloric intake, adipose tissue weights (brown, inguinal and epididymal), adipocytes per field and adipocyte size. Statistical analysis for parametric data was used Anova One Way followed by Tuckey's test and for non-parametric data Kruskal-Wallis followed by Dunn's test. Results: The HH group showed a greater body weight gain than the CC after weaning. Lee index showed no differences between groups. There was a reduction in abdominal circumference in the HHOP group compared to the CC and HH. Calorie intake was higher in the HH group compared to the CC group. In brown adipose tissue, there was no difference between groups in tissue weight and adipocytes per field, but adipocyte size was larger in the HH and HHOP groups compared to the control. In the inguinal adipose tissue, the tissue weight of the HHOP was smaller in relation to the HH and this greater than the CC. There was a greater number of adipocytes per field in the HHOP group compared to the HH and smaller adipocytes size in the HHOP compared to the HH. In the epididymal adipose tissue, the weight of the tissue was greater in the HH compared to the CC, the number and size of adipocytes did not differ. Conclusion: The consumption of onion peel powder contributed to the reduction of white adipose tissue mass, greater control of adipocyte hypertrophy in the inguinal white adipose tissue, greater size of brown adipose tissue, in addition to contributing to the reduction of abdominal circumference in exposed rats. A high-fat diet, which may help to achieve greater homeostasis of adipose tissue. Likewise, quercetin supplementation seems to attenuate the deleterious effects of high-fat diet consumption on adipose tissue metabolism in rats.

 

COMMITTEE MEMBERS:
Presidente - 1066101 - JAIRZA MARIA BARRETO MEDEIROS
Interna - 3112241 - MARIA ESTER PEREIRA DA CONCEICAO MACHADO
Externo à Instituição - MARCELO BIONDARO GOIS - UFRB
Externo à Instituição - NELSON VINÍCIUS MELO ANDRADE
Externa à Instituição - GABRIELA DOS SANTOS PEREZ