Banca de DEFESA: HAYNA MALTA SANTOS

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : HAYNA MALTA SANTOS
DATE: 26/04/2022
TIME: 09:00
LOCAL: IGM Sala Virtual 5
TITLE:

BIOSIGNATURES OF INFLAMMATORY PATHWAYS IN TEGUMENTARY LEISHMANIASIS: AN INTEGRATED LOOK

KEY WORDS:

Tegumentary Leishmaniasis, arginase, polyamines, L. braziliensis, lipid mediators, Resolvina D1.

PAGES: 117
BIG AREA: Ciências Biológicas
AREA: Parasitologia
SUMMARY:

ABSTRACT INTRODUCTION: Tegumentary leishmaniasis (TL) is a parasitic disease that can result in wide spectrum clinical manifestations depending on host and parasite determinants. Understanding these characteristics in different clinical outcomes is important to identify novel therapeutic targets. Pentavalent antimonials are the first-line drugs used to treat Leishmaniosis. However, occurrence of treatment failure in Brazil can be as high as 45%. In this context, identification of potential biomarkers of disease severity or parasite control may favor the development of host-oriented therapies that may increase the clinical management of severe/complicated cases. AIM: In this study, we evaluated biomarkers of disease severity and therapeutic failure in patients with tegumentary leishmaniasis and the role of resolving in the resistance to Leishmania infection. RESULTS: Our results show that patients with DCL present a differential activation of the polyamine and amino acid pathway when compared to LCL and MCL and this pathway can be used as a biomarker of disease severity. In addition, we found a biosignature influenced by plasma proteins and lipid mediators that accurately predicted treatment failure in LT. Additional in vitro experiments using human neutrophils revealed that RvD1 promotes intracellular replication of L. braziliensis however, the mechanism behind this effect still needs to be investigated. CONCLUSION: The results suggest that the production pathways of polyamines and lipid mediators can be used as biomarkers of disease severity and therapeutic failure and that RvD1 favors parasite resistance, and can together serve as a potential therapeutic strategy

BANKING MEMBERS:
Externa à Instituição - CHRISTIANNE BANDEIRA DE MELO - UFRJ
Externa à Instituição - ELVIRA MARIA SARAIVA - UFRJ
Interna - 796.762.515-34 - JULIANA PERRONE BEZERRA DE MENEZES FULLAM - UFBA
Presidente - 028.288.917-55 - VALÉRIA DE MATOS BORGES - UFRJ
Interna - 2770540 - VIVIANE SAMPAIO BOAVENTURA DE OLIVEIRA