Banca de DEFESA: ISABELE DE PÁDUA CARVALHO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ISABELE DE PÁDUA CARVALHO
DATE: 20/12/2021
TIME: 09:00
LOCAL: IGM Sala Virtual 5
TITLE:

Evaluation of the role of the humoral response in the progression of arthralgia disease caused by the Chikungunya virus

KEY WORDS:

Chikungunya Virus, phase chronic, progression arthritis, humoral response

PAGES: 57
BIG AREA: Ciências Biológicas
AREA: Parasitologia
SUMMARY:

ABSTRACT INTRODUCTION: The Chikungunya virus is transmitted by the Aedes mosquito. In the acute phase of the disease, the individual has fever and joint pain, the subacute phase is characterized by the prolongation of symptoms in the acute phase and, finally, the chronic phase in which joint pain persists. At this stage, the vast majority of individuals infected with the virus develop chronic arthralgia. Thus, the CHIKV virus drew attention for being associated with debilitating joint pain affecting the quality of life of individuals for a long period. OBJECTIVE: Given the above, the aim of this study was to evaluate the role of the humoral response in the progression to chronic arthralgia caused by the Chikungunya Virus. MATERIALS AND METHODS: We employ the diagnostic method through ELISA (IgM and IgG) and PRNT50, PRNT80 and PRNT90 being a sensitive and specific test, respectively. RESULTS: We analyzed the kinetics of IgM and IgG antibody production along disease progression by ELISA and investigated the relationship of these neutralizing antibodies to disease progression through PRNT50, PRNT80 and PRNT90. Thus, the response is maintained after 2 years and it was found that there is a neutralizing response in the first days of infection in PRNT50. CONCLUSIONS: There is a neutralization response in the first days of the disease that prevents the infected individual from developing chronic arthralgia observed in PRNT50.

BANKING MEMBERS:
Externo à Instituição - RODRIGO HADDAD - UnB
Presidente - 2236977 - ANTONIO RICARDO KHOURI CUNHA
Interna - 796.762.515-34 - JULIANA PERRONE BEZERRA DE MENEZES FULLAM - UFBA