Banca de DEFESA: GABRIELA LÉDA RÊGO DE AMORIM

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : GABRIELA LÉDA RÊGO DE AMORIM
DATA : 05/06/2020
HORA: 08:30
LOCAL: De forma remota (online)
TÍTULO:

RELEVANCE OF THE EVALUATION OF FUNCTIONALITY IN THE THERAPEUTIC APPROACH OF PATIENTS WITH BIPOLAR DISORDER.

PALAVRAS-CHAVES:

Functioning. Bipolar disorder. Systematic review. Residual symptoms. Subsyndromal symptoms

PÁGINAS: 51
GRANDE ÁREA: Ciências da Saúde
ÁREA: Medicina
RESUMO:

Background: Bipolar disorder (BD) is marked by a considerable degree of morbi-mortality, and it is frequently associated with expressive functional impairment (FI). Even in euthymia state and with adequate treatment, individuals usually maintain a gap between symptomatic and functional recovery, which underscores the significance of targeting this phenomenon through patient care. Objective: To perform a meta-analysis about the prevalence of FI in euthymic patients with BD, as assessed only by the Functioning Assessment Short Test (FAST). Then, reflect on the conceptual differences between residual and subsyndromal symptoms, which are frequently associated to functional outcome. Method: Meta-analyses were performed, searching for relevant papers published from 2007 to 2019 in Medline, Embase, Cochrane, PsycINFO databases and via hand-searching, without language restrictions. 1128 studies were initially identified, 13 of which were ultimately chosen based on the eligibility criteria. A two-step meta-analysis was performed using the mean difference with a 95% confidence interval for continuous variables and proportion estimation with a fixed-effects model for categorical variables. Subsequently, another article was made in the letter format to explore the conceptual differences between residual and subsyndromal symptoms. Results: all FAST domains showed worse FI in patients than in healthy controls. The prevalence of FI domains were as follows: global, 58.6%; occupational, 65.6%; cognitive, 49.2%; autonomy, 42.6%; interpersonal relationships, 42.1%; leisure, 29.2%; and financial issues, 28.8%. The presence of residual depressive symptoms was the most frequently cited variable associated with FI. Conclusions: This study highlights the relevance of functional assessment through patient care, as it constitutes one meaningful endpoint of response to treatment. It is also essential to standardize residual/subsyndromal terminologies in order to facilitate the comprehension of evolution of the disease and allow the warrant of finer-grained management strategies.

MEMBROS DA BANCA:
Externo à Instituição - ANDRE CARVALHO CARIBE DE ARAUJO PINHO - EBMSP
Interno - 3215394 - ANGELA MARISA DE AQUINO MIRANDA SCIPPA
Externo ao Programa - 7287642 - ESDRAS CABUS MOREIRA