Banca de DEFESA: CLARA DE LIMA BRITES ALVES

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
DISCENTE : CLARA DE LIMA BRITES ALVES
DATA : 05/05/2020
HORA: 08:00
LOCAL: De forma remota (online)
TÍTULO:

IMMUNOLOGICAL ACTIVATION, PRO-INFLAMMATORY CYTOKINES AND CONVENTIONAL RISKS FOR CARDIOVASCULAR DISEASES IN HIV PATIENTS, IN BAHIA, BRAZIL

PALAVRAS-CHAVES:

CARDIOVASCULAR DISEASES; HIV 

PÁGINAS: 61
GRANDE ÁREA: Ciências da Saúde
ÁREA: Medicina
RESUMO:

Background: Cardiovascular events (CVE) are an increasing cause of morbimortality for HIV patients. The antiretroviral therapy (ART), persistent immune activation, and life style are factors that can increase CVE for such patients. We performed a case-control study to evaluate the role of coinfections and immune markers associated with CVE.
Methods: We included patients under ART, with undetectable plasma viral load ≥12 months. Patients presenting any condition of risk for CVE were considered cases, and those without CVE risk conditions were controls. History of viral infections (Epstein–Barr virus, hepatitis C virus, hepatitis B virus, and cytomegalovirus), exposure to antiretroviral drugs, time since HIV diagnosis/under ART, and life style (demographics, weight, smoking, alcohol, and illicit drug use) were assessed. CD4/CD8 nadir and current counts, nadir and current CD4/CD8 ratio, immune activation markers (CD4CD38HLADR, CD8CD38HLADR), and serum levels of eight cytokines [IL-2, IL-4, IL-6, IL-10, tumoral necrosis factor-alpha (TNF-α), interferon gamma, macrophage inflammatory proteins 1 alpha, and interferon-inducing protein (IP-10)] were measured.
Results: Two-thirds of patients were males. Cases (N = 106) were older (52.8 vs 49.5 years, p = 0.002), had higher levels of creatinine (0.97 vs 0.87 mg/dL, p = 0.002) and IL-6 (0.67 vs 0.52 pg/mL, p = 0.04) than controls (N = 114). There was no difference between groups regarding frequency of CD4CD39HLADR+ or CD8CD38HLADR+ cells. We found a significant correlation (all patients) between increased frequency of CD4CD38HLADR+ cells and levels of IP-10 (r = 0.171, p = 0.02) and TNF-α (r = 0.187, p = 0.01). Levels of IL-6 (r = 0.235, p = 0.02), TNF-α (r= 0.267, p = 0.01), and IP-10 (r = 0.205, p = 0.04) were correlated with CD4CD38HLADR+ cells, in controls. Higher frequency of CD4CD38HLADR+ cells was also correlated with levels of IP-10 (r = 0.271, p = 0.04) in patients presenting with arterial hypertension. Frequency of CD4CD38HLADR+ cells was negatively correlated with levels of IL-2 (r = −0.639, p = 0.01) and IL-6 (r = −0.0561, p = 0.03) in patients with hypercholesterolemia. No association was detected between viral infections or smoking/alcohol use and immune activation markers.
Conclusion: Our results indicate IL-6 levels are associated with increased CV risk. Activated CD4+ T cells were associated with increased levels of proinflammatory cytokines.

MEMBROS DA BANCA:
Interno - 268.439.351-68 - EDUARDO MARTINS NETTO - UFBA
Externo à Instituição - FABIANNA MARCIA MARANHÃO BAHIA SOUZA
Interno - 2292247 - LILIANE ELZE FALCAO LINS KUSTERER
Externo à Instituição - NANCI FERREIRA DA SILVA
Externo ao Programa - 981037 - ROQUE ARAS JUNIOR