Banca de QUALIFICAÇÃO: ANA MARIA BORGES DA PAIXÃO BARRETO

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : ANA MARIA BORGES DA PAIXÃO BARRETO
DATE: 06/03/2024
TIME: 09:00
LOCAL: Instituto de Saúde Coletiva
TITLE:

SEROLOGICAL EVIDENCE OF SEOV IN URBAN SLUMS AND ASSOCIATED RISK FACTORS 

KEY WORDS:

Seul virus; Norway rats; humans, Tropical; urban slum

PAGES: 40
BIG AREA: Ciências Biológicas
AREA: Ecologia
SUMMARY:

Seoul Orthohantavirus (SEOV) is a worldwide species of hantavirus, transmitted by the Rattus norvegicus. Hantaviruses pose emerging and global threats to public health, affecting approximately 30,000 individuals worldwide annually. SEOV is transmitted to humans through the inhalation of viral particles present in the excreta of infected rodents. Despite the widespread distribution of reservoir hosts and their close association with humans, few studies have characterized the prevalence of SEOV in human populations, likewise, the associated risk factors particularly, in urban environments. Here, we evaluated the circulation of SEOV among rodent populations in vulnerable urban communities in Salvador, the probable human contact with infected reservoir hosts, and the likely risk factors encouraging human transmission through rodent-human contact. We conducted a serological study on rodent and human populations from four vulnerable urban communities in Salvador, Brazil. To detect contact with SEOV, we used a commercial ELISA kit. Our results found serological evidence in 32% of captured rodents (37/117) and 14% (91/646) in humans. Using an automated model selection approach to understand variables associated with human exposure, we found that the probability of contact with the virus decreased with increasing age, with garbage collection and previous infection with Leptospira spp negatively associated with SEOV exposure. However, garbage accumulation, rodent sightings, and working as a mason constituted the final model that best explains exposure in the collected dataset. These results highlight that vulnerable urban communities in Salvador are exposed to SEOV. Our results provide valuable information about the potential risks of SEOV in humans, especially among vulnerable residents of tropical urban communities. This information should aid the improvement of the hantavirus surveillance system in Brazil, where it is somewhat underreported. Additionally, it should contribute to the prevention strategies of individuals and professionals directly at risk of regular contact with the rodent reservoir of SEOV.

COMMITTEE MEMBERS:
Interno - ***.125.575-** - EDUARDO MENDES DA SILVA - UFBA
Interno - 2187819 - FEDERICO COSTA
Interno - 3054284 - PAVEL DODONOV
Externo à Instituição - HUSSEIN KHALIL
Externa à Instituição - IANEI DE OLIVEIRA CARNEIRO - UFBA
Externa à Instituição - RENATA CARVALHO DE OLIVEIRA PIRES DOS SANTOS