Banca de DEFESA: IVA SOUZA DE JESUS
Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.DISCENTE : IVA SOUZA DE JESUS
DATA : 12/11/2021
HORA: 14:00
LOCAL: defesa virtual pelo meet
TÍTULO:
NEW FORMAL [3+3]CYCLOADDITION REACTIONS OBETWEEN 3-CARBOXICUMARINS AND ENAMINONES IN THE SYNTHESIS OF CARBO- AND POLYFUNCTIONALIZED HETEROCYCLES
PALAVRAS-CHAVES:
Enaminones, coumarins, reactivity.
PÁGINAS: 281
GRANDE ÁREA: Ciências Exatas e da Terra
ÁREA: Química
SUBÁREA: Química Orgânica
ESPECIALIDADE: Síntese Orgânica
RESUMO:
In this work, the study of the reactivity of coumarino-3-carboxylic acids against the five-membered cyclic enaminones in formal aza-[3+3] cycloaddition reactions was carried out for the first time. Thus, 08 new polyfunctionalized indolizidine core were obtained with satisfactory yield (47-94%) and 03 new dihydropyridones in yields between 59 and 68% were obtained. Additionally, from synthetic applications of suitable indolizidinones, it was possible to access new coumarin-indolizidinic hybrids via trans-ring reactions, promoted by Fe(acac)3 and oxidative aromatization reactions, catalyzed by Pd/C (10 mol%). In addition, the reactivity of coumarin-3-carboxylic acids to secondary acyclic enaminones was investigated to obtain 10 unprecedented cyclohexenones, with an adequate level between 70 and 99%. In addition, two new azabicycles were accessed from reactions between primary acyclic enaminones and coumarin-3-carboxylic acid.
MEMBROS DA BANCA:
Presidente - 1215450 - SILVIO DO DESTERRO CUNHA
Interno - 1507716 - MAURICIO MORAES VICTOR
Interno - 1068075 - JORGE MAURICIO DAVID
Interna - 1490845 - VALERIA BELLI RIATTO
Interno - 2166886 - ANDRE ALEXANDRE VIEIRA
Externo à Instituição - ANTONIO CARLOS BENDER BURTOLOSO - USP
Externa à Instituição - VERA LUCIA EIFLER-LIMA - UFRGS
Externo à Instituição - DIMAS JOSÉ DA PAZ LIMA - UFAL
Externa à Instituição - FERNANDA ANDREIA ROSA - UEM
Externo à Instituição - KLEBER THIAGO OLIVEIRA - UFSCAR
Externa à Instituição - ROSSIMIRIAM PEREIRA DE FREITAS - UFMG