Banca de DEFESA: RICARDO LEAL CUNHA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
DISCENTE : RICARDO LEAL CUNHA
DATA : 25/02/2021
HORA: 08:30
LOCAL: Instituto de Química
TÍTULO:

OCCURRENCE OF SYNTHETIC DRUGS IN THE NORTHEASTERN REGION OF BRAZIL: A STUDY ON THE PREVALENCE OF AMPHETAMINE TYPE STIMULANTS (ATS) AND NEW PSYCHOACTIVE SUBSTANCES (NPS) IN THE STATES OF BAHIA AND SERGIPE

PALAVRAS-CHAVES:

synthetic drugs; amphetamine-type stimulants; new psychoactive substances; LC-MS/MS; GC-MS; qNMR

PÁGINAS: 251
GRANDE ÁREA: Ciências Exatas e da Terra
ÁREA: Química
SUBÁREA: Química Analítica
ESPECIALIDADE: Análise de Traços e Química Ambiental
RESUMO:

The illicit market for synthetic drugs is characterized by the wide variety of psychoactive substances of different chemical and pharmacological classes, such as amphetamine-type stimulants and new psychoactive substances that have appeared more frequently in this market in the last twenty years. A recent report released by the Oswaldo Cruz Foundation in July 2019, showed that approximately 33.8% of young Brazilians between 12 and 34 years old have consumed some illegal substance throughout their lives. In view of this scenario, knowledge about the chemical composition of these drugs, the nature and quantity of the active substances present, is relevant in several aspects. The main one is related to public health and the need for adequate medical care for people who ingest hitherto unknown psychoactive substances. Another important aspect is the knowledge about the composition of these drugs apprehended by the police, in order to establish adequate chemical and toxicological analysis procedures in the forensic laboratories. In this study, 21 substances were identified among classic synthetic drugs and new psychoactive substances, in seizures that occurred in 17 cities in Bahia and Sergipe, using GC-MS, FTIR and NMR. In order to investigate the composition of ecstasy and amphetamine stimulants, seized between 2014 and 2019, an analytical method was developed to determine 12 substances of interest using GC-MS. Analyzes of 203 tablets showed that MDMA, the main component of ecstasy, was found in 57% of the samples, in amounts between 27.3 –187.1 mg / tablet. Mixtures of MDMA, MDA, caffeine and synthetic cathinones were observed in 34% of the analyzed ecstasy tablets. Analyzes of illicit tablets of “Nobésio” showed that clobenzorex and caffeine were the only substances found in 93% of the samples in amounts between 2.15 - 34.5 mg/tablet and 4.94 - 118.3 mg/tablet, respectively. After these findings, an analytical method was developed to determine 11 synthetic drugs in 50 blood samples, employing protein precipitation and LC-MS / MS, with the aim of investigating the use of these drugs in post-mortem cases. In five samples, MDMA, MDA, amphetamine and clobenzorex were identified, in concentrations ranging from <5.0 ng/mL (MDMA) to 389.3 ng/mL (amphetamine). These results have shown that the illicit trade in synthetic drugs in these states has significantly contributed to indiscriminate consumption and the occurrence of cases of intoxication in several fatal events.

MEMBROS DA BANCA:
Presidente - 1143276 - PEDRO AFONSO DE PAULA PEREIRA
Interno(a) - 1553299 - GISELE OLIMPIO DA ROCHA
Interno(a) - 1215450 - SILVIO DO DESTERRO CUNHA
Interno(a) - 285528 - VANIA PALMEIRA CAMPOS
Externo(a) à Instituição - WILSON ARAUJO LOPES
Externo(a) à Instituição - JOSÉ LUIZ DA COSTA - UNICAMP
Externo(a) à Instituição - SANDRO NAVICKIENE - UFS
Externo(a) à Instituição - ALAIN GAUJAC - IFSE