Banca de DEFESA: RAFAEL DOS SANTOS COSTA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
DISCENTE : RAFAEL DOS SANTOS COSTA
DATA : 13/08/2020
HORA: 08:30
LOCAL: Comunidade Acadêmica Federada da Rede Nacional de Pesquisa, no endereço eletrônico https://conferenc
TÍTULO:

Phytochemical study and biological activity of Homalolepis bahiensis Turcz. (Simaroubaceae).

PALAVRAS-CHAVES:

Homalolepis bahiensis; Simaroubaceae; quasinoids; citotoxity; canthin-6-one; photoluminescent.

PÁGINAS: 363
GRANDE ÁREA: Ciências Exatas e da Terra
ÁREA: Química
SUBÁREA: Química Orgânica
RESUMO:

This work describes the phytochemical study of Homalolepis bahiensis (Simaroubaceae), an endemic plant at brazilian northeast region. The phytochemical study of the roots and stems was carried out and provided the isolation and identification of 7 quassinoids, 5 canthin-6-one alkaloids, 1 coumarin and 1 phenolic compound. The quassinoids 12-dehydro-klaineanone and 11,12-diacetyl-chaparrinone are described for the first time. Their chemical structures were elucidated by one- and two-dimensional experiments of Nuclear Magnetic Resonance and all molecular formulas was confirmed using mass spectrometry. In vitro citotoxity evaluation of dichloromethane extract of the roots and 5 isolated compounds was carried out against tumoral cell lines and demonstrated promising results. This work also describes the photoluminescent properties of the extracts from the roots, roots barks and stems of H. bahiensis. The observed fluorescent properties guided the cell stainig experiments as well as the isolation and characterization of the cell-labeling properties of 3 canthin-6- one alkaloids at HEP-G2 and HFib under microscopy evaluation. Confocal fluorescence showed remarkable cellular labeling properties of the extracts and isolated compounds.

MEMBROS DA BANCA:
Externo ao Programa - 1536719 - CRISTIANE FLORA VILLARREAL
Interno - 1148522 - ELIANE DE OLIVEIRA SILVA
Interno - 1756798 - ELISANGELA FABIANA BOFFO
Presidente - 1165099 - EUDES DA SILVA VELOZO
Externo à Instituição - JOSEAN FECHINE TAVARES - UFPB
Interno - 3768242 - PAULO ROBERTO RIBEIRO DE JESUS
Externo ao Programa - 1477001 - REGINA MARIA GERIS DOS SANTOS
Externo ao Programa - 3477451 - VICTOR DIOGENES AMARAL DA SILVA