Banca de DEFESA: GEIZIANE ALVES SANTOS

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : GEIZIANE ALVES SANTOS
DATA : 20/12/2019
HORA: 14:00
LOCAL: Instituto de Química
TÍTULO:

SYNTHESIS OF 3-PYRIDAZINONE AND 2-PYROLIDONE VIA AZAANNULATION OF 3-HYDROXYINDOLES WITH HYDRAZINE

PALAVRAS-CHAVES:

AZAANNULATION, ISATINE, HETEROCYCLE.

PÁGINAS: 130
GRANDE ÁREA: Ciências Exatas e da Terra
ÁREA: Química
SUBÁREA: Química Orgânica
ESPECIALIDADE: Síntese Orgânica
RESUMO:

In this work were developed methodologies, studies and reactivity of new heterocycles with biologic potential. It was employed isatin as starting material, a versatile and attractive N-heterocycle that allows various functionalization such as aldolic reactions against a representative group of ketones. As products was obtained 3-hydroxyindolin-2-ones which are isatin derivatives and have a carbonyl group at position-2 of five membered-ring and a quaternary carbon at 3-position. In addittion, they are structural skeletons found in various pharmacological agents and biologically active alkaloids. From the 3-hydroxy 2-indoles was synthesized, against hydrazine, via aza-anullation [4+2] and under mild conditions pyridazinones, which are five-or six-membered heterocycles with two nitrogen atoms and can be found in various compounds with biological activities. In order to broaden the scope to other sites, from isatin and acrylonitrile were sinthesized new hydroxyindoles called MBH-Morita-Baylis-Hillman adducts, which are nuclei of great interest in the synthetic field due to the atomic economy as well as the ability to generate densely functionalized alkenes of great synthetic utility. In this work, the adducts were synthesized comparatively by classic and optimized methodology and reacted with hydrazine hidrate employing microwave heating. It was observed the formation of pyrrolidinones via aza-anullation [4+1], instead of pyridazinones. Under controlled conditions, pyrrolidinones led to quinolinone derivatives.

MEMBROS DA BANCA:
Presidente - 1215450 - SILVIO DO DESTERRO CUNHA
Interno - 1068075 - JORGE MAURICIO DAVID
Interno - 1490845 - VALERIA BELLI RIATTO
Interno - 1148522 - ELIANE DE OLIVEIRA SILVA
Interno - 2166886 - ANDRE ALEXANDRE VIEIRA
Interno - 1507716 - MAURICIO MORAES VICTOR
Externo à Instituição - AMENSON TRINDADE GOMES - UFRB
Externo à Instituição - SANDRO JOSE GREGO - UFES
Externo à Instituição - LOURENCO LUIS BOTELHO DE SANTANA - UNEB
Externo à Instituição - FERNANDO DE CARVALHO DA SILVA - UFF
Externo à Instituição - ÂNGELO DE FÁTIMA - UFMG