Banca de DEFESA: JAQUELINE REIS DE SOUZA BISPO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : JAQUELINE REIS DE SOUZA BISPO
DATA : 25/09/2019
HORA: 09:00
LOCAL: UFBA
TÍTULO:

BIOREDUCTION AND OXIDATIVE KINETIC RESOLUTION OF OXYGENATED COMPOUNDS USING THE MARINE SPONGE Cliona varians

PALAVRAS-CHAVES:

ENANTIOSELECTIVE SYNTHESIS, BIOTRANSFORMATIONS, CLIONA VARIANS

PÁGINAS: 126
GRANDE ÁREA: Ciências Exatas e da Terra
ÁREA: Química
SUBÁREA: Química Orgânica
ESPECIALIDADE: Síntese Orgânica
RESUMO:

Biocatalysis is an important tool in organic synthesis, especially in the synthesis of chiral molecules, due to the biological activity associated with these compounds. Brazil has a vast biological diversity, interesting from the biocatalytic point of view, which is still underused. The need to obtain chiral compounds through cleaner synthetic routes (Green Chemistry) makes important the controlled exploitation of fauna and flora, in order to develop new biocatalysts. In this work, the biocatalytic potential of the Cliona varians marine sponge was studied in stereoselective bioreduction reactions of pro-chiral ketone available in the laboratory (acetophenone, nitroacetophenone and acetylfuran) and in the oxidative kinetic resolution of racemic secondary alcohols chemically prepared [p-nitrophenylethanol, p-methoxyphenylethanol and 1-(2-furylethanol)]. To obtain racemic standards for comparison with the products obtained by the bioreductions, the ketones were reduced chemically (yields 75-97%). The reactional products were characterized by spectroscopic techniques (IV, ¹H-RMN e ¹³C-RMN). The experiments were carried out by means of glucose and fructose as additives, and also when there were no additives. The biotransformation reactions were evaluated for 3, 5 and 7 days and analyzed through chiral CG. Hydroxylated products were obtained with moderate conversions and ee ranged from 20% to 84%, alternating the absolute R or S configuration depending on the additive employed.

MEMBROS DA BANCA:
Presidente - 1490845 - VALERIA BELLI RIATTO
Interno - 1507716 - MAURICIO MORAES VICTOR
Interno - 1068075 - JORGE MAURICIO DAVID
Externo ao Programa - 2765101 - ADEMIR EVANGELISTA DO VALE
Externo à Instituição - CLAYTON QUEIROZ ALVES - UEFS