Banca de DEFESA: ALBA DE OLIVEIRA DUTRA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : ALBA DE OLIVEIRA DUTRA
DATA : 02/08/2019
HORA: 09:00
LOCAL: instituto de quimica
TÍTULO:

SYNTHESIS OF FUNCTIONALIZED 1-AZADIENES DERIVATIVES OF ENAMINONAS VIA REACTIONS MULTICOMPONETES AND ITS EMPLOYMENT IN THE PREPARATION OF PIRAZÓIS

PALAVRAS-CHAVES:

enaminone

PÁGINAS: 109
GRANDE ÁREA: Ciências Exatas e da Terra
ÁREA: Química
SUBÁREA: Química Orgânica
ESPECIALIDADE: Síntese Orgânica
RESUMO:

1-Azadienes are of great interest in organic synthesis because of their vast versatility in synthetic applications. This study brings innovative reactions to the methodology used to obtain 1-azadienes. Such methodology involves four reagents in two steps that are added in the one-pot way to the reaction medium (multicomponent reactions), so that the products formed incorporate structural characteristics of each of the reagents. Through this methodology, seven analogous azadienes were synthesized, resulting in four new ones to the literature. Still in the pseudo tetracomponent, three tetracyclic pyrazole compounds were synthesized. Obtaining different compounds demonstratesthe influence of the different substituents (activators and disactivants) on the diazonium salts, which are determinants for the final product. The azadienes synthesized by means that methodology were submitted to reactivity tests against oxidizing and reducing agents, in order to study possible synthetic transformations. The results were nitrogenous aromatic heterocycles of five members belonging to the azole class. In addition, trisubstituted and tetrasubstituted pyrazoles were synthesized in a novel way. This class of compounds is important because they belong to a set of molecules that, in addition to high medicinal potential, have a wide range of other applications, such as: pharmacological, agricultural, materials science and photographic.

MEMBROS DA BANCA:
Interno - 2166886 - ANDRE ALEXANDRE VIEIRA
Interno - 1148522 - ELIANE DE OLIVEIRA SILVA
Interno - 1507716 - MAURICIO MORAES VICTOR
Externo à Instituição - DIMAS JOSÉ DA PAZ LIMA - UFAL
Externo à Instituição - FERNANDA ANDREIA ROSA - UEM