Banca de DEFESA: TAMIRES MARIEL MUNIZ MILHAZES
Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.DISCENTE : TAMIRES MARIEL MUNIZ MILHAZES
DATA : 01/08/2019
HORA: 09:00
LOCAL: Instituto de Química
TÍTULO:
Ruthenium(II) base Schiff complexes: preparation, characterization, and evaluation as potential P450-bioinspired systems
PALAVRAS-CHAVES:
simazine, Ru(salen), P450-bioinspired complexes
PÁGINAS: 80
GRANDE ÁREA: Ciências Exatas e da Terra
ÁREA: Química
SUBÁREA: Química Inorgânica
ESPECIALIDADE: Química Bio-Inorgânica
RESUMO:
Brazil is one of the countries with the highest agrochemicals consumption, among which stands out the simazine, an herbicide of the triazine class. Besides it being harmful to directly exposed humans, this substance is also responsible for several damages to the environment, specifically to water sources. Therefore, it is necessary to research about the oxidation of this molecule, in order to provide a better base of toxicological profile, as well as to assist in the remediation of systems that are affected by this pesticide. In living systems, the superfamily of enzymes that perform the metabolism of exogenous molecules (pesticides, dyes and drugs) are the cytochromes P450. These monoxygenases perform the biotransformation of substrates in a fast, versatile and high effective way, that the use of synthetic model-systems that mimics the catalytic function of P450 has been studied over the past three decades. In this context, the objective of this work was to synthesize, characterize and evaluate the catalytic activity of P450 in ruthenium salen complexes against oxidation of simazine. For comparative effect, compounds of iron and manganese with salen were also synthesized, [RuNOCl(Salen-N(Et)2)], [MnCl(Salen-N(Et)2)], [FeCl(Salen-N(Et)2)], [RuNOCl(Salen-MeCl)] and [MnCl(Salen-MeCl)]. These coordination compounds were characterized by spectral techniques (FTIR and UV-Vis) and electrochemical (cyclic voltammetry). The analyzes indicated the efficiency of the complexation, as well as the high-transition states of the metals that possibly act in bioinspired oxidative reaction mechanism. The catalytic assays of these complexes in the simazine oxidation were performed with the respective oxygen donors: H2O2, PhIO, NaClO and m-CPBA and the oxidation products were separated by HPLC. The catalysts obtained satisfactory results in the substrate conversion, particularly for [Ru(Salen-MeCl)]/NaClO system which achieved 26.4%. Regarding to the product distribution, the most selective catalyst was the [Ru(Salen-N(Et)2)] since in the presence of all oxidants it was reached only two products.
MEMBROS DA BANCA:
Presidente - 2151820 - LUCAS BOMFIM BOLZON
Interno - 2151753 - JOICY SANTAMALVINA DOS SANTOS
Interno - 1148522 - ELIANE DE OLIVEIRA SILVA
Interno - 1215450 - SILVIO DO DESTERRO CUNHA
Externo à Instituição - JULIANA FONSECA DE LIMA - UERJ
Externo à Instituição - VALÉRIA PRISCILA DE BARROS - UFS
Externo à Instituição - ALESSANDER ACACIO FERRO - UNEB