Banca de DEFESA: ROMÁRIO DA SILVA RAMOS

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ROMÁRIO DA SILVA RAMOS
DATE: 29/02/2024
TIME: 14:00
LOCAL: Sala de Seminários do IQ
TITLE:

Reactivity of isatins with 2-aminonaphthoquinones promoted by barbituric acid and derivatives: synthesis and in silico evaluation of analogues of the pentacyclic alkaloid alpkinidine

KEY WORDS:

Cascade reaction, isatin, 2-amino-naphthoquinone

PAGES: 115
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Orgânica
SPECIALTY: Síntese Orgânica
SUMMARY:

In this work, the development and optimization of a new synthetic route were carried out to access analogous pentacycles of the alkaloid alpkinidine simply in a single step, without the need for the use of a column for purification or the use of metals as catalysts. Using ethanol, which is non-toxic and renewable, as a solvent. The use of microwaves allowed us to access the alpkinidine analogues containing the ABCD rings of the alkaloid in a reduced time and with moderate to good yields. Nine new analogues were synthesized using five-substituted isatins and N-substituted 2-amino-naphthoquinones as reagents and thiobarbituric acid as the promoter. An in-silico evaluation of the absorption, distribution, metabolism, excretion and toxicity (ADMET) properties of the synthesized analogues was also carried out.

COMMITTEE MEMBERS:
Presidente - 1215450 - SILVIO DO DESTERRO CUNHA
Interno - 1068075 - JORGE MAURICIO DAVID
Interno - 2166886 - ANDRE ALEXANDRE VIEIRA
Interno - 1276681 - RONAN BATISTA
Interno - 1507716 - MAURICIO MORAES VICTOR
Externa à Instituição - VANDERLUCIA FONSECA DE PAULA
Externa à Instituição - SABRINA TEIXEIRA MARTINEZ - UFRJ
Externo à Instituição - RODRIGO DE PAULA - UFRB