Banca de DEFESA: WELLINGTON CORREIA DE CARVALHO

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : WELLINGTON CORREIA DE CARVALHO
DATE: 31/08/2023
TIME: 14:30
LOCAL: Sala de Seminários
TITLE:

EVALUATION OF THE USE OF DRUGS FOR CHRONIC CARDIOMETABOLIC DISEASES IN THE BIOACCESSIBILITY OF ESSENTIAL ELEMENTS IN NUTRITIVE FLOURS

KEY WORDS:

Bioaccessibility; nutritious flour; ICP OES

PAGES: 100
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Analítica
SPECIALTY: Análise de Traços e Química Ambiental
SUMMARY:

Simultaneous administration of drugs with food may compromise the bioaccessibility and absorption of nutrients. The aim of this study was to evaluate the influence of the use of losartan potassium, metformin hydrochloride and simvastatin on the in vitro bioaccessibility of micronutrients (Cu, Fe, Mn and Zn) in nutritious flour sold in Bahia, Brazil. The experimental procedure consisted of the in vitro extraction of the bioaccessible fraction of Cu, Fe, Mn and Zn in flours – with and without Losartan Potassium (50 mg), Metformin Hydrochloride (500 mg) and Simvastatin (20 mg) – using the Unified Method of Bioaccessibility (UBM), simulating the conditions of the gastrointestinal tract. For the decomposition of the samples (nutritive flour and residue) a digester block with a closed system was used. To determine the total (flour and residual fraction) and bioaccessible content of micronutrients, inductively coupled plasma optical emission spectrometry (ICP OES) was used. For oat flour, the bioaccessible contents (µg g-1) without the addition of drugs were: Cu 5.86 ± 0.21; Fe 32.80 ± 1.32; Mn 87.90 ± 1.90; Zn 30.33 ± 2.05, with bioaccessibility ranging from 31.5 for Fe to 99% for Mn. The in vitro extraction method was validated by mass balance, with recovery values from 89.78% for Cu to 101.94% for Mn. The range of bioaccessible contents (µg g-1) were: Cu (< 4.14), Fe (32.10 ± 0.20 – 54.10 ± 2.03), Mn (81.40 ± 0.93 – 93.22 ± 0.80) and Zn (< 10.80 – 29.11 ± 2.20). The estimate of the bioaccessibility of Cu, Mn and Zn in oat flour was compromised in the presence of Losartan Potassium, Metformin Hydrochloride and Simvastatin (p < 0.05). Thus, we can infer that chemical interactions can occur between drugs and micronutrients. Therefore, the results highlight that these drugs can interfere with the bioaccessibility of Cu, Fe, Mn and Zn in flours, in patients who use these drugs, suggesting their rational use in future investigations.

COMMITTEE MEMBERS:
Presidente - 282814 - MARIA DAS GRACAS ANDRADE KORN
Interna - 2721446 - DANIELE CRISTINA MUNIZ BATISTA DOS SANTOS
Externo à Instituição - ANIBAL DE FREITAS SANTOS JUNIOR - UNEB
Externo à Instituição - WALTER NEI LOPES DOS SANTOS - UNEB
Externo à Instituição - DANILO JUNQUEIRA LEÃO
Externa à Instituição - LAÍS ARAÚJO SOUZA - UFPE
Externa à Instituição - DÉBORA DE ANDRADE SANTANA - UNEB