Banca de DEFESA: JULIANA AZEVEDO DA PAIXAO

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : JULIANA AZEVEDO DA PAIXAO
DATE: 18/08/2023
TIME: 08:15
LOCAL: Virtual
TITLE:

CHEMICAL CHARACTERIZATION, BIOLOGICAL ACTIVITIES AND TECHNOLOGICAL PROSPECTION OF Ananas comosus variations FROM THE PINEAPPLE BAG. 

KEY WORDS:

phenolics, Ananas, cinnamic acid derivatives, validation, chemical composition

PAGES: 110
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Orgânica
SPECIALTY: Química dos Produtos Naturais
SUMMARY:

The Bromeliaceae family comprises a vast diversity of species, with Brazil accounting for approximately 40% of this total. Some plants in the family have medicinal properties and are used in the treatment of numerous conditions and they are also used as food. The Active Pineapple Germplasm Bank (BAG-Pineapple) of Embrapa Cassava and Fruit is the largest germplasm bank of pineapples in the world, contributing to the selection of genotypes of agronomic, ornamental, and industrial value. This research aimed to carry out a survey of the chemical substances isolated and/or identified in the leaves of Ananas comosus, to analyze the pharmacological activities described in the literature, to prospect patents for products based on  Ananas comosus  and to perform a comparative phytochemical study of varieties of A. comosus from BAG-Pineapple. According to the literature, the presence of organic acids, flavonoids, esters, steroids and other metabolites, mainly phenolic compounds, and flavonoids, have been described. These substances have several pharmacological activities, especially abortive, antioxidant, lipid-lowering and hypoglycemic activities. The main patents filed are related to medicinal use, such as antineoplastics, anti-inflammatory drugs and drugs for the gastrointestinal tract. Regarding the phytochemical screening of A. comosus access leaves, the presence of special metabolites was evidenced, mainly phenolic compounds, flavonoids and saponins. The methodology validation and quantification of p-coumaric acid and ferulic acid were performed, p-coumaric acid contents were found between 24.83-881.65 μg/mg of extract and ferulic acid between 15.68-971.30 μg/mg of extract. In the phytochemical study of Ananas comosus var. erectifolius  the substances lupeol, stigmasterol, β-sitosterol, daucosterol, quercetin, p-coumaric acid, ferulic acid and a semipurified fraction with the presence of ellagic acid were identified and isolated. It is noteworthy to pointing out that this is the first study to identify and isolate these substances in Ananas comosus var. erectifolius, and the first to identify/isolate lupeol and ellagic acid in Ananas comosus. Thus, it contributes to the characterization of the chemical substances present  in the leaves of A. comosus of the  BAG-Pineapple and provides relevant information for the study of the pharmacological activity and the potential application in the pharmaceutical industry.

 

 

COMMITTEE MEMBERS:
Presidente - 1068075 - JORGE MAURICIO DAVID
Interna - 1148522 - ELIANE DE OLIVEIRA SILVA
Interno - 1551430 - FABIO DE SOUZA DIAS
Externo ao Programa - 2765101 - ADEMIR EVANGELISTA DO VALE - UFBAExterno à Instituição - HUGO NEVES BRANDAO - UEFS
Externa à Instituição - ERIKA MARIA DE OLIVEIRA RIBEIRO - UNEB