Banca de DEFESA: KLAUBER VIANA CARDOSO

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : KLAUBER VIANA CARDOSO
DATE: 18/08/2023
TIME: 08:30
LOCAL: Defesa Virtual
TITLE:

Chemical composition of the roots of  Bowdichia virgilioides (Leguminoseae)

KEY WORDS:

Bowdichia virgilioides, sucupira, isoflavone , alkaloid

PAGES: 146
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Orgânica
SPECIALTY: Química dos Produtos Naturais
SUMMARY:

Bowdichia virgiliodes Kunt. is a medium-sized tree, comprised in the Papilionoideae subfamily and belonging to the Leguminoseae family. The species composes the flora in an endemic way among the tropical forests of South America and is popularly known as sucupira in several regions of Brazil, with predominance in the state of Bahia. The Bowdichia genus is contained in a set of high chemical and pharmaceutical potential, which have been explored over the years, but which depend on greater protection and investigative chemical studies. Its use in traditional medicine includes stem barks with tonic, antidiarrheal, antiulcerative, hypoglycemic, rheumatological properties and seeds acting as a dermatological antimicrobial, for example. The production of alkaloids by this plant may represent evidence of the parental relationship with other genera belonging to the Leguminoseae family. Thus, this work was proposed for the phytochemical study of the root of the species Bowdichia virgiloides using column chromatography to analyze the methanolic, hexanic, ethyl acetate and butanolic extracts. Triterpenoid compounds were identified, such as lupeol, stigmasterol and sitosterol, plus a hopan triperpene, the 17β-H-Δ21 hopan. The latter is not yet described in the species and also not evidenced in the genus. Among the flavonoids identified, it should also be noted the 7,3'-dihydroxy-4'–methoxyisoflavone (BV-1A), 7,5,4'-trihydroxyisoflavone (BV-1B); 2'- hydroxy-4',6',3,4-tetramethoxyhalcone (BV-5) and 7,2'-dihydroxy -4'-methoxyisoflavone (BV7) isolated from the methanolic phase; plus compounds (5,7-dihydroxy-4'-methoxyisoflavone) (EBV-2), 5,7,3-trihydroxy-4'-methoxyisoflavone (EBV-5D), 7,4'-dimethoxy-5-hydroxyisoflavone (EBV-7); 7,2',4'-trihydroxy-5,3-dimethoxy-flavan (EBV-13A), 7,4-dihydroxy-7- methoxy-flavan (EBV-13B); 5,7,4'-trihydroxy-8-glycoflavone (EBV-14); 5,7,4'-trihydroxy-3'- glycoflavone (EBV-22A). isolated from the ethyl acetate phase and which had not yet been cited in the species. Other flavonoids cited in the literature as originating from the species B. virgilioides could be confirmed as formononetin and pseudobaptigenin. However, in the present study, no alkaloids cited as common in the species were found. The structural determination of the substances was performed by mass spectrometric technique and infrared spectroscopy, nuclear magnetic resonance and comparison with literature data

COMMITTEE MEMBERS:
Interno - 1068075 - JORGE MAURICIO DAVID
Interno - 1276681 - RONAN BATISTA
Interna - 1490845 - VALERIA BELLI RIATTO
Externo ao Programa - 1788171 - BRUNO OLIVEIRA MOREIRA - UFBAExterna à Instituição - MARIA DE FATIMA VANDERLEI