Banca de DEFESA: LEONARDO DE OLIVEIRA AGUIAR

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : LEONARDO DE OLIVEIRA AGUIAR
DATE: 28/07/2023
TIME: 14:00
LOCAL: Instituto de Química
TITLE:

SYNTHESIS OF COUMARIN, CHALCONE AND NEOFLAVONOID DERIVATIVES WITH POTENTIAL BIOLOGICAL ACTIVITIES

KEY WORDS:

organic synthesis; Flavonoids; Chalcones; Neoflavonoids; Coumarins.

PAGES: 140
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Orgânica
SPECIALTY: Síntese Orgânica
SUMMARY:

Flavonoids and coumarins are defined as classes of specialized metabolites, present in plants from different families. The relevance of the study concerning flavonoids and coumarins is because compounds from these classes have considerable biological and pharmacological activities. The diversity and quantity of studies published annually on both classes of compounds corroborate the scientific importance of these polyphenols. In order to expand knowledge and contribute to the specialized literature, this PhD thesis proposes the synthesis of new ester derivatives of coumarins, as well as the development of a new methodology for obtaining flavonoids, especially chalcones and neoflavonoids, for further investigation on their pharmacological properties. Fifteen (15) coumarin esters were prepared via greener Steglich reaction, with yields between 15 and 93%. Ten (10) of them were synthesized for the first time. Coumarin derivatives were evaluated on their cytotoxic and antimicrobial potential. In addition, ten (10) compounds from the class of flavonoids were prepared, in a study of different phenols reactivity against cinnamic acid in the presence of BF₃.OEt₂. This study allowed access chalcones, flavanone and neoflavonoids, obtained from the substrate’s structural differences. Yields in this synthesis varied between 10 and 67%, and the products obtained were evaluated on their cytotoxic potential. This thesis will also present preliminary results of synthesis of hybrid compounds, formed by the combination between the coumarin moiety and other bioactive molecules, such as geraniol and tacrine.

COMMITTEE MEMBERS:
Presidente - 1068075 - JORGE MAURICIO DAVID
Interna - 2454639 - CALINE GOMES FERRAZ
Interna - 1490845 - VALERIA BELLI RIATTO
Interno - 1507716 - MAURICIO MORAES VICTOR
Externo ao Programa - 2765101 - ADEMIR EVANGELISTA DO VALE - UFBAExterno à Instituição - CLAYTON QUEIROZ ALVES
Externo à Instituição - JOSEAN FECHINE TAVARES - UFPB
Externa à Instituição - VANDERLUCIA DOS ANJOS CRUZ - UESB