Banca de DEFESA: BENIVALDO NASCIMENTO DOS SANTOS JUNIOR
Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.STUDENT : BENIVALDO NASCIMENTO DOS SANTOS JUNIOR
DATE: 02/06/2023
TIME: 08:00
LOCAL: Instituto de Química
TITLE:
XANTHONES ISOLATED FROM THE STEM AND ROOT OF Kielmeyera coriacea (CALOPHYLLACEAE) AND EVALUATION OF THEIR ANTIMICROBIAL ACTIVITIES
KEY WORDS:
Kielmeyera coriacea (Calophyllaceae), xanthones, antimicrobial activity
PAGES: 111
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Orgânica
SPECIALTY: Química dos Produtos Naturais
SUMMARY:
This paper describes the isolation of five xanthones present in the roots and stem extract of Kielmeyera coriacea Mart. (Calophyllaceae) and the evaluation of the antimicrobial activity of these xanthones. The specimens were collected in Parque do Cercado in Chapada Diamantina - Bahia. The stem and roots of the plant were submitted separately to maceration in hexane and ethyl acetate, generating the respective hexanic and ethyl acetate extracts. The extracts, in turn, were subjected to several chromatographic processes, and an unpublished xanthone was obtained from the fractions of the ethyl acetate extract of the roots, in addition to an unpublished xanthone and three already known, having been obtained from the ethyl acetate extract from the stem. The substances were identified using spectrometric methods, such as one-dimensional (1H and 13C) and two-dimensional (gHMBC and gHSQC) Nuclear Magnetic Resonance and mass spectrometry. The antimicrobial activity of xanthones was evaluated by the broth dilution method, and one of the already known xanthones showed activity against Micrococcus luteus, Staphylococcus aureus, Bacillus cereus, Bacillus subtilis and Candida albicans and one of the new xanthones showed activity against Micrococcus luteus.
COMMITTEE MEMBERS:
Presidente - 1756798 - ELISANGELA FABIANA BOFFO
Interno - 3768242 - PAULO ROBERTO RIBEIRO DE JESUS
Interna - 2454639 - CALINE GOMES FERRAZ
Externa à Instituição - DANIELA APARECIDA CHAGAS DE PAULA - UNIFAL-MG
Externo à Instituição - LUCAS SILVA ABREU - UFF
Externa à Instituição - DANIELLE FERREIRA DIAS - UNIFAL-MG
Externa à Instituição - LOURDES CARDOSO DE SOUZA NETA - UNEB