Banca de DEFESA: EDSON EVANGELISTA SILVA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : EDSON EVANGELISTA SILVA
DATE: 07/10/2022
TIME: 14:00
LOCAL: Sala de seminários do IQ
TITLE:

SYNTHESIS OF AZA-POLY-HETEROCYCLES THROUGH THE AZA-ANNELATION [3+3] OF 2,5-DIAMINO-1,4-BENZOQUINONE AGAINST DIFFERENT POLYCARBONYLATED ELECTROPHILS

KEY WORDS:

enaminones, quinolones, heterocycles

PAGES: 140
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Orgânica
SPECIALTY: Síntese Orgânica
SUMMARY:

In this work, the study of the reactivity of 2,5-diamino-1,4-benzoquinone against arylidenes derived from Meldrum acid, barbituric acid and 1,3-indandione in aza-ringing- [3+3] reactions was carried out for the first time, 06 new quinolinetrionic nuclei were obtained in yields between 20 and 93%, in addition to 04 new quinolinetetraonic nuclei in yields between 52 and 98%. Additionally, from the synthetic application of the 6-amino-4-phenyl-quinolinetrione obtained, it was possible to access a new benzoxazole-dihydroquinoline hybrid via oxidative cyclization reactions, promoted by Pd/C (20 mol%). In addition, the reactivity of 2,5-diamino-1,4-benzoquinone against ninhydrin was also investigated and it was possible to obtain an unprecedented pentacycle compound, with a yield of 92%. In addition, a study for the application of 5-amino-isatin in obtaining quinolinic nuclei, generated two new hybrids between isatin/quinoline with 43% and isatin/naphthoquinone with 65% yield.

BANKING MEMBERS:
Presidente - 1215450 - SILVIO DO DESTERRO CUNHA
Interno - 2166886 - ANDRE ALEXANDRE VIEIRA
Interno - 1068075 - JORGE MAURICIO DAVID
Interno - 1507716 - MAURICIO MORAES VICTOR
Interno - 1276681 - RONAN BATISTA
Externa ao Programa - 3205960 - SABRINA TEIXEIRA MARTINEZ
Externo à Instituição - FERNANDO DE CARVALHO DA SILVA - UFF
Externo à Instituição - SANDRO JOSE GREGO - UFES
Externo à Instituição - DAVID RODRIGUES DA ROCHA - UFF