Banca de DEFESA: SUÉLEM MARIA SANTANA PINHEIRO FERREIRA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
DISCENTE : SUÉLEM MARIA SANTANA PINHEIRO FERREIRA
DATA : 27/03/2019
HORA: 08:00
LOCAL: INSTITUTO DE SAÚDE COLETIVA
TÍTULO:

THE EFFECT OF THE PERIODONTAL CONDITION ON THE DETERMINATION OF THE CLINICAL EVOLUTION OF CHRONIC RENAL DISEASE

PALAVRAS-CHAVES:

Periodontitis. Renal Insufficiency. Biomarkers. Mortality.

PÁGINAS: 138
GRANDE ÁREA: Ciências da Saúde
ÁREA: Saúde Coletiva
SUBÁREA: Epidemiologia
RESUMO:

Some investigations address periodontitis as a non-traditional risk factor for complications
and progression of CKD. Thus, the objective of this study was to investigate the association
of periodontal conditions and periodontitis with CKD in individuals under hemodialysis
treatment. The results were organized in three scientific papers. The first article included a
systematic review with meta-analysis of studies investigating the association of periodontitis
with outcomes related to the complication or progression of CKD. The meta-analytic
association measures indicated a positive association of periodontitis with hypoalbuminemia
(PR = 2.47, 95% CI: 1.43-4.26), high levels of C-reactive protein (PR = 1.39, 95% CI = 1.07-
1.81), death due to disease (RR = 2.29, 95% CI: 1.67-3.15) and death from all causes (RR =
1.73, 95% CI = 1.32-2.27). The other two articles are part of a prospective cohort study of
prognosis, performed with 217 individuals with CKD under hemodialysis treatment in Feira
de Santana-BA. Data were collected through questionnaire, oral examination and medical
records. The follow up of the individuals was performed between August 2016 and December
2018. The second paper investigated the association of periodontal parameters with the
evolution of laboratory biomarkers used in clinical monitoring. The CAL was negatively
correlated with mean serum calcium levels (p = 0.021), phosphorus (p = 0.020) and albumin
(p = 0.025) at 12 months follow up. In addition, individuals with higher CAL had significant
changes in the levels of phosphorus (p = 0.053) and alkaline phosphatase (p = 0.005) in the
first six months of follow-up. Individuals with higher PD had a significant increase in serum
alkaline phosphatase levels (p = 0.008) between 0 and 6 months of follow-up. In addition,
dental loss was negatively correlated with mean levels of phosphorus (p <0.001) and albumin
(p = 0.001) over a 12-month follow-up period. In the third paper, the effect of periodontal
condition on survival and risk of death was estimated. Individuals with greater tooth
(p=0.025) loss and greater CAL (p<0.01) had lower survival. Those with the highest CAL
also had the risk of death increased more than twice (HR = 2.88; 95% CI: 1.55-5.36 / adjusted
HR = 2.28; 95% CI: 1.12-4.62). It was concluded that the periodontal condition was
positively associated with the biomarkers of complication and progression of CKD.

MEMBROS DA BANCA:
Externo à Instituição - CARLOS ALBERTO LIMA DA SILVA - UEFS
Externo ao Programa - 2767574 - CAROLINA LARA NEVES
Externo à Instituição - ISAAC SUZART GOMES FILHO - UEFS
Interno - 285683 - MARIA DA CONCEICAO NASCIMENTO COSTA
Interno - 285660 - MARIA ISABEL PEREIRA VIANNA
Externo à Instituição - SIMONE SEIXAS DA CRUZ - UFRB