Banca de DEFESA: JUAN PABLO AGUILAR TICONA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : JUAN PABLO AGUILAR TICONA
DATA : 18/02/2019
HORA: 08:30
LOCAL: INSTITUTO DE SAÚDE COLETIVA
TÍTULO:

Incidence of clinical outcomes and developmental changes in children born during the ZIKV outbreak: a cohort study in an urban community in Brazil.

PALAVRAS-CHAVES:

ZIKV

PÁGINAS: 62
GRANDE ÁREA: Ciências da Saúde
ÁREA: Saúde Coletiva
RESUMO:

Northeast Brazil was the epicenter of the Zika epidemic in 2015, yet little if any prospective information exists on Zika virus (ZIKV) transmission among pregnant women from the region and clinical outcomes of their infants. We have been conducting a community-based prospective study of leptospirosis among urban slum residents since January 2013 in Salvador, Brazil. From this population, we identified women who were pregnant from January 2015 to June 2016 and identified incident Zika seroconversion events among participants by analyzing biannually collected samples for the ZIKV35 monoclonal antibody using the Blockade of Binding (BoB) assay. We evaluated adverse outcomes during pregnancy, birth and infancy by interviewing mothers and performing anthropometric measurements as well as neurologic (Hammersmith Infant Neurological Exam, HINE), audiometric and ophthalmological evaluations and examinations with Bayley Scales of Infant Development III. Among a cohort of 655 participants, 66 (10%) had at least one pregnancy during the study period. We completed follow-up for 46 (70%) of the 66 women, of whom Zika seroconversion occurred prior to, during and after pregnancy in 25 (54%), 13 (28%), and 1 (2%), respectively. The 46 infants did not have evidence of microcephaly or congenital defects at birth. However, the 13 infants of mothers who seroconverted during pregnancy had increased risk of having a low cognitive score < 1SD (RR 2.96; 95% CI 1.32 – 6.63) than the 33 infants of mothers who did not seroconvert during pregnancy (4 of 13 [31%] vs. 2 of 33 [6%], respectively). Similarly, infants of mothers who seroconverted during pregnancy had increased risk (RR 6.82: 1.54 – 30.17) of having altered behavioral audiometry findings than infants of mothers who did not seroconvert during pregnancy (5 of 13 [39%] vs. 2 of 31 [7%], respectively). These findings suggest that a significant proportion of infants exposed in utero to ZIKV develop developmental deficiencies despite the absence of clinically evident neurological sequelae.

MEMBROS DA BANCA:
Interno - 2286127 - DARCI NEVES DOS SANTOS
Interno - 2187819 - FEDERICO COSTA
Externo ao Programa - 2349789 - JAMARY OLIVEIRA FILHO